Transcription Factor

Accessions: OTX2_MOUSE (HOCOMOCO 10), P80206 (JASPAR 2024)
Names: Homeobox protein OTX2, Orthodenticle homolog 2, OTX2_MOUSE
Organisms: Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 289
Pfam Domains: 39-95 Homeobox domain
153-235 Otx1 transcription factor
Sequence:
(in bold interface residues)
1 MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKT 60
61 RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKSSPARE 120
121 VSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYT 180
181 QASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLST 240
241 QGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL
Interface Residues: 17, 21, 38, 39, 40, 41, 42, 80, 81, 83, 84, 87, 88, 91, 92, 95
3D-footprint Homologues: 1e3o_C, 4j19_B, 3cmy_A, 2h1k_B, 1puf_A, 3d1n_M, 5zfz_A, 1fjl_B, 1ig7_A, 6a8r_A, 1jgg_B, 2lkx_A, 1nk2_P, 1zq3_P, 3lnq_A, 6es3_K, 7q3o_C, 2ld5_A, 7psx_B, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 1au7_A, 4cyc_A, 2r5y_A, 1puf_B, 6m3d_C, 5flv_I, 3l1p_A, 2hos_A, 1b72_A, 5zjt_E, 3a01_E, 5hod_A, 1le8_A, 4qtr_D, 8g87_X, 6wig_A, 1o4x_A, 1du0_A
Binding Motifs: OTX2_MOUSE.H10MO.C|M01272 kwkmwrGGATTArak
PH0130.1 kdwrgGGATTAAtydtc
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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