Transcription Factor
| Accessions: | PDX1_HUMAN (HOCOMOCO 10), P52945 (JASPAR 2024) |
| Names: | Glucose-sensitive factor, GSF, IDX-1, Insulin promoter factor 1, Insulin upstream factor 1, IPF-1, Islet/duodenum homeobox-1, IUF-1, Pancreas/duodenum homeobox protein 1, PDX-1, PDX1_HUMAN, Somatostatin-transactivating factor 1, STF-1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 283 |
| Pfam Domains: | 147-203 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQG 60 61 SPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLPFP 120 121 WMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELA 180 181 VMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPP 240 241 PPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR |
| Interface Residues: | 147, 148, 149, 150, 188, 189, 191, 192, 195, 196, 199, 200, 203 |
| 3D-footprint Homologues: | 6a8r_A, 1ig7_A, 2h1k_B, 5zfz_A, 1puf_A, 3cmy_A, 1fjl_B, 3d1n_M, 1nk2_P, 1zq3_P, 3lnq_A, 1jgg_B, 2lkx_A, 7q3o_C, 2ld5_A, 6es3_K, 2hos_A, 1b72_A, 5jlw_D, 4xrs_G, 3a01_E, 3rkq_B, 6m3d_C, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 7psx_B, 5hod_A, 2xsd_C, 7xrc_C, 1e3o_C, 1le8_A, 1au7_A, 4qtr_D, 1o4x_A, 1du0_A |
| Binding Motifs: | MA0132.2 symATTAr PDX1_HUMAN.H10MO.C|M01430 rSTmATTAG MA0132.3 ymATTA |
| Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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