Transcription Factor

Accessions: T025942_1.02 (CISBP 1.02), CEBPA_MOUSE (HOCOMOCO 10), P53566 (JASPAR 2024)
Names: Cebpa, T025942_1.02;, C/EBP alpha, CCAAT/enhancer-binding protein alpha, CEBPA_MOUSE
Organisms: Mus musculus, Rattus norvegicus
Libraries: CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:bZIP
Length: 359
Pfam Domains: 283-335 Basic region leucine zipper
288-339 bZIP transcription factor
Sequence:
(in bold interface residues)
1 MESADFYEVEPRPPMSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEHET 60
61 SIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAVMSA 120
121 GAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQ 180
181 PPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHAAPALGAA 240
241 GLPGPGSALKGLAGAHPDLRTGGGGGGSGAGAGKAKKSVDKNSNEYRVRRERNNIAVRKS 300
301 RDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA
Interface Residues: 289, 290, 293, 294, 296, 297, 300, 301
3D-footprint Homologues: 2wt7_A, 1nwq_C, 6mg1_B, 5t01_B, 2c9l_Z, 5vpe_D, 2dgc_A
Binding Motifs: M0304_1.02 rTtdcghaAy
CEBPA_MOUSE.H10MO.B|M01031 trTTktGmAAta
MA0102.1 TtkygCAAyvyb
MA0102.2 TtkygCAAy
Binding Sites: MA0102.1.1
MA0102.1.10
MA0102.1.11
MA0102.1.12
MA0102.1.13
MA0102.1.14
MA0102.1.15
MA0102.1.16
MA0102.1.17
MA0102.1.18
MA0102.1.2
MA0102.1.3
MA0102.1.4
MA0102.1.5
MA0102.1.6
MA0102.1.7
MA0102.1.8
MA0102.1.9
Publications: Grange T., Roux J., Rigaud G., Pictet R. Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor. Nucleic Acids Res. 19:131-139 (1991). [Pubmed]
Related annotations: PaperBLAST

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