Transcription Factor

						

			
Accessions: Q9BYE0 (JASPAR 2024)

			
Names: bHLH factor Hes7, bHLHb37, Class B basic helix-loop-helix protein 37, Hairy and enhancer of split 7, HES7_HUMAN, hHes7, Transcription factor HES-7
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9BYE0
Length: 225
Pfam Domains:     17-67 Helix-loop-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 MVTRDRAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILE   60
  61 FAVGYLRERSRVEPPGVPRSPVQDAEALASCYLSGFRECLLRLAAFAHDASPAARAQLFS  120
 121 ALHGYLRPKPPRPKPVDPRPPAPRPSLDPAAPALGPALHQRPPVHQGHPSPRCAWSPSLC  180
 181 SPRAGDSGAPAPLTGLLPPPPPPHRQDGAPKAPLPPPPAFWRPWP
Interface Residues: 20, 21, 24, 25, 53, 55
3D-footprint Homologues: 4h10_A, 1am9_A, 1an4_A, 7ssa_L, 4h10_B, 8osl_O, 8osl_P, 5nj8_C, 5v0l_B
Binding Motifs: MA0822.1 yGGCACGTGCCr
UN0489.1 ggCACGTGcCrwtsGCGCsm
UN0490.1 grCrCGTGsyrywaGGCGCsm
UN0575.1 rCwCGTGksGGATTA
UN0489.2 ggCACGTGcCrwtsGCGCs
UN0490.2 grCrCGTGsyrywaGGCGCs
			
Publications: Chen J, Kang L, Zhang N. Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis. Genesis 43:196-204 (2005). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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