Transcription Factor
| Accessions: | TFE2_MOUSE (HOCOMOCO 10), P15806 (JASPAR 2024) |
| Names: | Immunoglobulin enhancer-binding factor E12/E47, TCF-3, TFE2_MOUSE, Transcription factor 3, Transcription factor A1, Transcription factor E2-alpha |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 651 |
| Pfam Domains: | 547-600 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKSRPASLGGTQFAGSGLEDRPSSGSW 60 61 GSSDQNSSSFDPSRTYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGT 120 121 LSQAGFLPGELSLSSPGPLSPSGIKSSSQYYPSFPSNPRRRAADGGLDTQPKKVRKVPPG 180 181 LPSSVYPPSSGDSYSRDAAAYPSAKTPSSAYPSPFYVADGSLHPSAELWSTPSQVGFGPM 240 241 LGDGSSPLPLAPGSSSVGSGTFGGLQQQDRMGYQLHGSEVNGSLPAVSSFSAAPGTYSGT 300 301 SGHTPPVSGAAAESLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQG 360 361 LPGTSQWPRAGAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASDLHGLLPGHG 420 421 ALTTSFTGPMSLGGRHAGLVGGSHPEEGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSY 480 481 SGLGRAGTTAGASEIKREEKEDEEIASVADAEEDKKDLKVPRTRTSPDEDEDDLLPPEQK 540 541 AEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSSEKPQTKLLILHQAVAVILSLE 600 601 QQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL |
| Interface Residues: | 502, 503, 504, 506, 507, 510, 548, 551, 552, 554, 555, 556, 558, 559 |
| 3D-footprint Homologues: | 5b7j_A, 7z5k_B, 2ypa_A, 6g1l_A, 6od3_F, 4h10_B, 7d8t_A, 2ypa_B, 2ql2_A, 2ql2_D |
| Binding Motifs: | PB0089.1 atcmvCAGGTGcraamw PB0193.1 arrgcCAGATGkyyssg TFE2_MOUSE.H10MO.A|M01390 ybsCAsCTGyyychgyybyy MA0092.1 srTCTGGmwt |
| Binding Sites: | MA0092.1.1 MA0092.1.10 MA0092.1.11 MA0092.1.12 MA0092.1.13 MA0092.1.14 MA0092.1.15 MA0092.1.16 MA0092.1.17 MA0092.1.18 MA0092.1.19 MA0092.1.2 MA0092.1.20 MA0092.1.3 MA0092.1.4 MA0092.1.5 MA0092.1.6 MA0092.1.7 MA0092.1.8 MA0092.1.9 |
| Publications: | Hollenberg S. M., Sternglanz R., Cheng P. F., Weintraub H. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol. 15:3813-3822 (1995). [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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