Transcription Factor
Accessions: | NEUROD2 (HT-SELEX2 May2017), Q15784 (JASPAR 2024) |
Names: | ENSG00000171532, NEUROD2, bHLHa1, Class A basic helix-loop-helix protein 1, NDF2_HUMAN, NDRF, NeuroD-related factor, Neurogenic differentiation factor 2 |
Organisms: | Homo sapiens |
Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Uniprot: | Q15784 |
Notes: | TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 3b0, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3b0 |
Length: | 382 |
Pfam Domains: | 122-173 Helix-loop-helix DNA-binding domain 180-310 Neuronal helix-loop-helix transcription factor |
Sequence: (in bold interface residues) | 1 MLTRLFSEPGLLSDVPKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGAPGPARAAKPVPL 60 61 RGEEGTEATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSK 120 121 LRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSG 180 181 KRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYP 240 241 YPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLS 300 301 PPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLS 360 361 YDMHLHHDRGPMYEELNAFFHN |
Interface Residues: | 123, 126, 127, 129, 130, 131, 133, 134 |
3D-footprint Homologues: | 7z5k_B, 2ypa_A, 6od3_F, 2ypa_B, 2ql2_A, 2ql2_D |
Binding Motifs: | MA0668.1 rmCATATGky NEUROD2_2 rmCATATGyy NEUROD2_methyl_1 rmCATATGyy |
Publications: | Fong AP, Yao Z, Zhong JW, Cao Y, Ruzzo WL, Gentleman RC, Tapscott SJ. Genetic and epigenetic determinants of neurogenesis and myogenesis. Dev Cell 22:721-35 (2012). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.