Transcription Factor

Accessions: NEUROD2 (HT-SELEX2 May2017), Q15784 (JASPAR 2024)
Names: ENSG00000171532, NEUROD2, bHLHa1, Class A basic helix-loop-helix protein 1, NDF2_HUMAN, NDRF, NeuroD-related factor, Neurogenic differentiation factor 2
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q15784
Notes: TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 3b0, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3b0
Length: 382
Pfam Domains: 122-173 Helix-loop-helix DNA-binding domain
180-310 Neuronal helix-loop-helix transcription factor
Sequence:
(in bold interface residues)
1 MLTRLFSEPGLLSDVPKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGAPGPARAAKPVPL 60
61 RGEEGTEATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSK 120
121 LRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSG 180
181 KRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYP 240
241 YPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLS 300
301 PPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLS 360
361 YDMHLHHDRGPMYEELNAFFHN
Interface Residues: 123, 126, 127, 129, 130, 131, 133, 134
3D-footprint Homologues: 7z5k_B, 2ypa_A, 6od3_F, 2ypa_B, 2ql2_A, 2ql2_D
Binding Motifs: MA0668.1 rmCATATGky
NEUROD2_2 rmCATATGyy
NEUROD2_methyl_1 rmCATATGyy
Publications: Fong AP, Yao Z, Zhong JW, Cao Y, Ruzzo WL, Gentleman RC, Tapscott SJ. Genetic and epigenetic determinants of neurogenesis and myogenesis. Dev Cell 22:721-35 (2012). [Pubmed]
Related annotations: PaperBLAST

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