Transcription Factor
| Accessions: | RXRA (SMILE-seq 1.0) |
| Names: | Fragment, Q6P3U7_HUMAN, RXRA, RXRA protein |
| Organisms: | Homo sapiens |
| Libraries: | SMILE-seq 1.0 1 1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
| Uniprot: | Q6P3U7 |
| Notes: | TF family: Nuclear Receptor |
| Length: | 461 |
| Pfam Domains: | 17-127 Nuclear/hormone receptor activator site AF-1 134-202 Zinc finger, C4 type (two domains) 264-442 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING 60 61 MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP 120 121 AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID 180 181 KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL 240 241 AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL 300 301 LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 360 361 QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL 420 421 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQM |
| Interface Residues: | 143, 144, 146, 147, 153, 154, 156, 157, 160, 161, 185, 207, 209, 211, 214, 216 |
| 3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B |
| Binding Motifs: | NR1H4_RXRA_1 grGGTcAarGgky NR1H4_RXRA_2 grGkTCAtTGACCyy NR4A2_RXRA rrGGTCrtTGACCyc PPARA_RXRA awgtrGGtcAaAGGTcAt PPARG_RXRA mrrGGkyAawrGGtCAc RARA_RXRA rrGGTCAwgkarrGGtCA RXRA rRGGTCA VDR_RXRA mrGGtcavcrrGktcry |
| Publications: | Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.