Transcription Factor

Accessions: T014207_1.02 (CISBP 1.02), MYCN_HUMAN (HOCOMOCO 10), P04198 (JASPAR 2024)
Names: MYCN, T014207_1.02;, bHLHe37, Class E basic helix-loop-helix protein 37, MYCN_HUMAN, N-myc proto-oncogene protein
Organisms: Homo sapiens
Libraries: CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: family:bHLH
Length: 464
Pfam Domains: 9-372 Myc amino-terminal region
382-434 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPP 60
61 LSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGF 120
121 SAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELA 180
181 HPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPG 240
241 GRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTIT 300
301 VRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLK 360
361 SVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKV 420
421 VILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC
Interface Residues: 385, 386, 387, 389, 390, 393, 394, 398, 419
3D-footprint Homologues: 1an4_A, 7d8t_A, 4zpk_A, 7xq5_A, 5nj8_D, 1am9_A, 7rcu_E, 5eyo_A, 5v0l_A, 7ssa_L, 5gnj_I, 6g1l_A, 7xi3_A, 5i50_B, 2ypa_B
Binding Motifs: M3642_1.02 ymcCACGTGymv
MYCN_HUMAN.H10MO.B|M01343 cCACGTGs
MA0104.4 sgCCACGTGGcs
MA0104.5 CCACGTGG
Binding Sites: MA0104.5.15
MA0104.5.12 / MA0104.5.4 / MA0104.5.7 / MA0104.5.9
MA0104.5.1 / MA0104.5.19 / MA0104.5.2 / MA0104.5.20 / MA0104.5.5 / MA0104.5.6
MA0104.4.1
MA0104.4.10
MA0104.4.11
MA0104.4.12
MA0104.4.13
MA0104.4.14
MA0104.4.15
MA0104.4.16
MA0104.4.17
MA0104.4.18
MA0104.4.19
MA0104.4.2
MA0104.4.20
MA0104.4.3
MA0104.4.4
MA0104.4.5
MA0104.4.6
MA0104.4.7
MA0104.4.8
MA0104.4.9
MA0104.5.10 / MA0104.5.11 / MA0104.5.3 / MA0104.5.8
MA0104.5.13
MA0104.5.14
MA0104.5.16
MA0104.5.17
MA0104.5.18
Publications: Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed]
Related annotations: PaperBLAST

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