Transcription Factor

						

			
Accessions: LEF1 (SMILE-seq 1.0)

			
Names: LEF-1, LEF1, LEF1_HUMAN, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1-alpha
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: Q9UJU2
Notes: TF family: HMG
Length: 398
Pfam Domains:     1-213 N-terminal CTNNB1 binding
  294-357 Domain of unknown function (DUF1898)
  299-366 HMG (high mobility group) box
Sequence: 
(in bold interface residues)		   1 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE   60
  61 SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM  120
 121 NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS  180
 181 KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWQGQPVYPITGGFRQPYPSSLSVDTSMS  240
 241 RFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIK  300
 301 KPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHM  360
 361 QLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAY
Interface Residues: 301, 304, 306, 307, 310, 314, 325, 326, 327, 330, 368, 370, 372, 375, 377, 378, 379, 382
3D-footprint Homologues: 3u2b_C, 7m5w_A, 2gzk_A, 4s2q_D, 2lef_A, 4y60_C, 1j5n_A, 3f27_D, 6jrp_D, 1o4x_B, 1hry_A
Binding Motifs: LEF1 wbcCTTTGAW
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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