Transcription Factor

Accessions: FLI1_full (HumanTF 1.0), FLI1_Full (HumanTF2 1.0)
Names: FLI1, FLI1_HUMAN, Friend leukemia integration 1 transcription factor, Proto-oncogene Fli-1, Transcription factor ERGB
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: Q01543
Notes: Ensembl ID: ENSG00000151702; Full protein sequence; TF family: ETS; Clone source: hORFeome, Ensembl ID: ENSG00000151702; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: ETS; Clone source: Jolma et al. 2013
Length: 453
Pfam Domains: 114-197 Sterile alpha motif (SAM)/Pointed domain
280-362 Ets-domain
Sequence:
(in bold interface residues)
1 MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQ 60
61 PVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTN 120
121 ERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATT 180
181 LYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKEDPSYDSVRRGAWGNNMNSGLNK 240
241 SPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCI 300
301 TWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKF 360
361 DFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAAS 420
421 QYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY*
Interface Residues: 278, 333, 334, 336, 337, 338, 340, 341, 355
3D-footprint Homologues: 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B
Binding Motifs: FLI1_full_1 ACCGGAArTg
FLI1_full_2 aCCGGAwATCCGGt
FLI1_BHLHA15 wcCGGAAACATATGk
FLI1_CEBPB rvCGGAwrTTGCGCAAy
FLI1_CEBPD rmmGGAwATTGCGcAAy
FLI1_DLX2_1 rsMGGAAryaaTtA
FLI1_DLX2_2 rvmGGAArtsvsyaaTtar
FLI1_DLX2_2_3 ACCGGAArTgrsyAATTA
FLI1_DRGX aCCGGAwGyAATTAt
FLI1_ETV7 rsmGGAmGGAtdTCCgsb
FLI1_FIGLA rsmGGAwrCAssTGb
FLI1_FOXI1_1 GAAAACCGAAAM
FLI1_FOXI1_2 rcCGGAWGTTkay
FLI1_FOXI1_2_3 rtaAACAGGAwryd
FLI1_FOXI1_2_3_4 TGTtkmCGGAwrtg
FLI1_HOXB13_1 rccGGAArymrTwAa
FLI1_HOXB13_2 ACCGGAAGTCRTAAAa
FLI1_MAX accGGAAaCACGTGg
FLI1_ONECUT2 acCGGAWryrmtgrTCGAT
FLI1_TCF3 rCCGGAwrCAssTgy
FOXO1_FLI1 GwmAACAGGAAGTk
TEAD4_FLI1 ACCGGAAATrCc
TFAP4_FLI1_1 rscGGAwrCAgsTGg
TFAP4_FLI1_2 acCGGAAACAGCTGwy
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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