Transcription Factor

Accessions: T161877_1.02 (CISBP 1.02), P39001 (JASPAR 2024)
Names: T161877_1.02;, UME6, Negative transcriptional regulator of IME2, Regulator of inducer of meiosis protein 16, Transcriptional regulatory protein UME6, UME6_YEAST, Unscheduled meiotic gene expression protein 6
Organisms: Saccharomyces cerevisiae
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:Zinc cluster
Length: 836
Pfam Domains: 769-803 Fungal Zn(2)-Cys(6) binuclear cluster domain
Sequence:
(in bold interface residues)
1 MLDKARSQSKHMDESNAAASLLSMETTANNHHYLHNKTSRATLMNSSQDGKKHAEDEVSD 60
61 GANSRHPTISSASIESLKTTYDENPLLSIMKSTCAPNNTPVHTPSGSPSLKVQSGGDIKD 120
121 DPKENDTTTTTNTTLQDRRDSDNAVHAAASPLAPSNTPSDPKSLCNGHVAQATDPQISGA 180
181 IQPQYTATNEDVFPYSSTSTNSNTATTTIVAGAKKKIHLPPPQAPAVSSPGTTAAGSGAG 240
241 TGSGIRSRTGSDLPLIITSANKNNGKTTNSPMSILSRNNSTNNNDNNSIQSSDSRESSNN 300
301 NEIGGYLRGGTKRGGSPSNDSQVQHNVHDDQCAVGVAPRNFYFNKDREITDPNVKLDENE 360
361 SKINISFWLNSKYRDEAYSLNESSSNNASSNTDTPTNSRHANTSSSITSRNNFQHFRFNQ 420
421 IPSQPPTSASSFTSTNNNNPQRNNINRGEDPFATSSRPSTGFFYGDLPNRNNRNSPFHTN 480
481 EQYIPPPPPKYINSKLDGLRSRLLLGPNSASSSTKLDDDLGTAAAVLSNMRSSPYRTHDK 540
541 PISNVNDMNNTNALGVPASRPHSSSFPSKGVLRPILLRIHNSEQQPIFESNNSTAVFDED 600
601 QDQNQDLSPYHLNLNSKKVLDPTFESRTRQVTWNKNGKRIDRRLSAPEQQQQLEVPPLKK 660
661 SRRSVGNARVASQTNSDYNSLGESSTSSAPSSPSLKASSGLAYTADYPNATSPDFAKSKG 720
721 KNVKPKAKSKAKQSSKKRPNNTTSKSKANNSQESNNATSSTSQGTRSRTGCWICRLRKKK 780
781 CTEERPHCFNCERLKLDCHYDAFKPDFVSDPKKKQMKLEEIKKKTKEAKRRAMKKK
Interface Residues: 766, 777, 778, 779
3D-footprint Homologues: 6o19_A, 1hwt_C, 1pyi_A, 3coq_A, 1d66_B, 7uik_T
Binding Motifs: MA0412.1 TsGGCGGCTAwwT
M1779_1.02 mdcCgcGghk
MA0412.2 wwwTAGCCGCCsArv
MA0412.3 wwTAGCCGCCsA
Binding Sites: MA0412.2.1
MA0412.2.10 / MA0412.2.11
MA0412.2.11 / MA0412.2.12
MA0412.2.12 / MA0412.2.13 / MA0412.2.14 / MA0412.2.15
MA0412.2.13 / MA0412.2.14 / MA0412.2.15 / MA0412.2.16
MA0412.2.16 / MA0412.2.18 / MA0412.2.7 / MA0412.2.8
MA0412.2.17 / MA0412.2.19
MA0412.2.18 / MA0412.2.20
MA0412.2.19
MA0412.2.2
MA0412.2.20
MA0412.2.3
MA0412.2.4
MA0412.2.5 / MA0412.2.6
MA0412.2.6 / MA0412.2.7
MA0412.2.8 / MA0412.2.9
MA0412.2.10 / MA0412.2.9
MA0412.2.17
MA0412.2.5
MA0412.3.1
MA0412.3.10
MA0412.3.11
MA0412.3.12 / MA0412.3.14
MA0412.3.13 / MA0412.3.15 / MA0412.3.2
MA0412.3.16 / MA0412.3.7
MA0412.3.17
MA0412.3.18
MA0412.3.19
MA0412.3.20
MA0412.3.3
MA0412.3.4
MA0412.3.5
MA0412.3.6
MA0412.3.8
MA0412.3.9
Publications: Pachkov M, Erb I, Molina N, van Nimwegen E. SwissRegulon: a database of genome-wide annotations of regulatory sites. Nucleic acids research 35:D127-31 (2007). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.