Transcription Factor
| Accessions: | NFIC_HUMAN (HOCOMOCO 10), P08651 (JASPAR 2024) |
| Names: | CCAAT-box-binding transcription factor, CTF, NF-I/C, NF1-C, NFI-C, NFIC_HUMAN, Nuclear factor 1 C-type, Nuclear factor 1/C, Nuclear factor I/C, TGGCA-binding protein |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 508 |
| Pfam Domains: | 5-47 Nuclear factor I protein pre-N-terminus 70-170 MH1 domain 217-508 CTF/NF-I family transcription modulation region |
| Sequence: (in bold interface residues) | 1 MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDE 60 61 LLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDC 120 121 LRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYL 180 181 AYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVV 240 241 TGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYY 300 301 TSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVH 360 361 SGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQ 420 421 PGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPD 480 481 TSPANRSFVGLGPRDPAGIYQAQSWYLG |
| Interface Residues: | 40, 43, 44, 48, 250, 251 |
| 3D-footprint Homologues: | 2lkx_A, 8dc2_A |
| Binding Motifs: | MA1527.1 sTTGGCrysgTGCCArs NFIC_HUMAN.H10MO.A|M01364 tyyTGGCwsmswkCCmr MA0161.1 yTGGCa MA0161.2 twCTTGGCAsa MA0161.3 CTTGGCA MA1527.2 TTGGCrysgTGCCAr |
| Binding Sites: | MA0161.1.1 MA0161.1.10 MA0161.1.11 MA0161.1.12 MA0161.1.13 MA0161.1.14 MA0161.1.15 MA0161.1.16 MA0161.1.17 MA0161.1.18 MA0161.1.19 MA0161.1.2 MA0161.1.20 MA0161.1.3 MA0161.1.4 MA0161.1.5 MA0161.1.6 MA0161.1.7 MA0161.1.8 MA0161.1.9 MA0161.2.1 MA0161.2.10 MA0161.2.11 MA0161.2.12 MA0161.2.13 MA0161.2.14 MA0161.2.15 MA0161.2.16 MA0161.2.17 MA0161.2.18 MA0161.2.19 MA0161.2.2 MA0161.2.20 MA0161.2.3 MA0161.2.4 MA0161.2.5 MA0161.2.6 MA0161.2.7 MA0161.2.8 MA0161.2.9 MA0161.3.1 / MA0161.3.10 / MA0161.3.11 / MA0161.3.16 / MA0161.3.17 / MA0161.3.18 / MA0161.3.19 / MA0161.3.20 / MA0161.3.5 / MA0161.3.8 MA0161.3.12 / MA0161.3.15 / MA0161.3.9 MA0161.3.13 MA0161.3.14 MA0161.3.2 MA0161.3.3 MA0161.3.4 MA0161.3.6 MA0161.3.7 |
| Publications: | Roulet E, Busso S, Camargo A.A, Simpson A.J, Mermod N, Bucher P. High-throughput SELEX SAGE method for quantitative modeling of transcription-factor binding sites. Nature biotechnology 20:831-5 (2002). [Pubmed] Heng YH, Barry G, Richards LJ, Piper M. Nuclear factor I genes regulate neuronal migration. Neurosignals : (2012;20(3):159-67.). [Pubmed] |
| Related annotations: | PaperBLAST |
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