Transcription Factor
| Accessions: | ETV4_HUMAN (HOCOMOCO 10), P43268 (JASPAR 2024) |
| Names: | Adenovirus E1A enhancer-binding protein, E1A-F, ETS translocation variant 4, ETV4_HUMAN, Polyomavirus enhancer activator 3 homolog, Protein PEA3 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P43268 |
| Length: | 484 |
| Pfam Domains: | 7-339 PEA3 subfamily ETS-domain transcription factor N terminal domain 341-422 Ets-domain |
| Sequence: (in bold interface residues) | 1 MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHF 60 61 QETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHH 120 121 GEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGE 180 181 HSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQP 240 241 AVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYE 300 301 KPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFI 360 361 AWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF 420 421 VCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAYLPELAGPAQPFGPKG 480 481 GYSY |
| Interface Residues: | 393, 394, 396, 397, 398, 400, 401, 415 |
| 3D-footprint Homologues: | 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 4mhg_A, 2stt_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A |
| Binding Motifs: | MA0764.1 aCCGGAwrtr UN0569.1 aCCGGAAGTCGTWAAm ETV4_HUMAN.H10MO.B|M01128 saGGAARy MA0764.2 rcAGGAAGyr MA0764.3 aCCGGAAGtr MA0764.4 aCCGGAAGt UN0569.2 CCGGAAGTCGTWAAm |
| Binding Sites: | MA0764.2.1 / MA0764.2.10 / MA0764.2.11 MA0764.2.20 MA0764.2.12 MA0764.2.13 MA0764.2.14 MA0764.2.15 / MA0764.2.18 MA0764.2.16 / MA0764.2.17 / MA0764.2.19 MA0764.2.2 MA0764.2.3 MA0764.2.4 / MA0764.2.7 MA0764.2.5 MA0764.2.6 MA0764.2.8 MA0764.2.9 |
| Publications: | Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] Cooper C.D, Newman J.A, Aitkenhead H, Allerston C.K, Gileadi O. Structures of the Ets Domains of Transcription Factors ETV1, ETV4, ETV5 and FEV: Determinants of DNA Binding and Redox Regulation by Disulfide bond formation. The Journal of biological chemistry : (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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