Transcription Factor
| Accessions: | RFX2_HUMAN (HOCOMOCO 10), P48378 (JASPAR 2024) |
| Names: | DNA-binding protein RFX2, Regulatory factor X 2, RFX2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P48378 |
| Length: | 723 |
| Pfam Domains: | 1-156 RFX1 transcription activation region 200-264 RFX DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ 60 61 VQPVQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVA 120 121 ASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIE 180 181 NLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAAS 240 241 FGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPR 300 301 YRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDG 360 361 VTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDP 420 421 EGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKS 480 481 LEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSD 540 541 LNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHA 600 601 GSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEA 660 661 TGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSL 720 721 QGI |
| Interface Residues: | 239, 243, 256, 260, 265 |
| 3D-footprint Homologues: | 1dp7_P |
| Binding Motifs: | MA0600.2 sGTTrCCATGGyAACs MA0600.1 GTykCCaTGGCAACmrssv RFX2_HUMAN.H10MO.C|M01482 sssscsGTTGCCAkGGmrACsg MA0600.3 GTTrCCATGGyAAC |
| Binding Sites: | MA0600.1.1 MA0600.1.10 MA0600.1.11 / MA0600.1.13 MA0600.1.12 / MA0600.1.8 MA0600.1.14 MA0600.1.15 MA0600.1.16 MA0600.1.17 MA0600.1.18 MA0600.1.19 MA0600.1.2 MA0600.1.20 MA0600.1.3 MA0600.1.4 MA0600.1.5 MA0600.1.6 MA0600.1.7 MA0600.1.9 |
| Publications: | Emery P., Strubin M., Hofmann K., Bucher P., Mach B., Reith W. A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol. Cell. Biol. 16:4486-4494 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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