Transcription Factor

						

			
Accessions: Q9BZE0 (JASPAR 2024)

			
Names: GLI-similar 2, GLIS2_HUMAN, Neuronal Krueppel-like protein, Zinc finger protein GLIS2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9BZE0
Length: 524
Pfam Domains:   224-246 Zinc-finger double domain
  235-257 Zinc finger, C2H2 type
  249-276 Zinc-finger double domain
  263-287 Zinc finger, C2H2 type
  293-317 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MHSLDEPLDLKLSITKLRAAREKRERTLGVVRPRALHRELGLVDDSPTPGSPGSPPSGFL   60
  61 LNSKFPEKVEGRFSAAPLVDLSLSPPSGLDSPNGSSSLSPERQGNGDLPPVPSASDFQPL  120
 121 RYLDGVPSSFQFFLPLGSGGALHLPASSFLTPPKDKCLSPDLPLPKQLVCRWAKCNQLFE  180
 181 LLQDLVDHVNDYHVKPEKDAGYCCHWEGCARHGRGFNARYKMLIHIRTHTNEKPHRCPTC  240
 241 SKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGC  300
 301 HKRYTDPSSLRKHIKAHGHFVSHEQQELLQLRPPPKPPLPAPDGGPYVSGAQIIIPNPAA  360
 361 LFGGPGLPGLPLPLAPGPLDLSALACGNGGGSGGGGGMGPGLPGPVLPLNLAKNPLLPSP  420
 421 FGAGGLGLPVVSLLAGAAGGKAEGEKGRGSVPTRALGMEGHKTPLERTESSCSRPSPDGL  480
 481 PLLPGTVLDLSTGVNSAASSPEALAPGWVVIPPGSVLLKPAVVN
Interface Residues: 177, 179, 180, 183, 187, 190, 191, 217, 218, 219, 220, 221, 222, 223, 224, 227, 230, 245, 246, 247, 248, 249, 251, 252, 255, 275, 276, 277, 278, 279, 280, 281, 282, 283, 285, 305, 306, 307, 308, 309, 310, 311, 312, 313
3D-footprint Homologues: 1tf6_A, 7ysf_A, 5yel_A, 3uk3_C, 8cuc_F, 1tf3_A, 5v3j_F, 6ml4_A, 2gli_A, 1g2f_F, 4x9j_A, 2i13_A, 5kl3_A, 6wmi_A, 5ei9_F, 7eyi_G, 8h9h_G, 5k5i_A, 8gn3_A, 6e94_A, 7n5w_A, 1ubd_C, 2jpa_A, 7y3l_A, 6jnm_A, 5und_A, 2drp_D, 2kmk_A, 8ssu_A, 6blw_A, 5kkq_D, 6u9q_A, 1llm_D, 8ssq_A, 1mey_C, 7w1m_H, 2lt7_A, 7y3m_I, 6a57_A, 1f2i_J, 7txc_E, 2wbs_A, 5yj3_D, 4m9v_C
Binding Motifs: MA0736.1 kACCCCCCrCramG
			
Publications: Lichti-Kaiser K, ZeRuth G, Kang HS, Vasanth S, Jetten AM. Gli-similar proteins: their mechanisms of action, physiological functions, and roles in disease. Vitam Horm : (2012;88:141-71.). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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