Transcription Factor
| Accessions: | Kr (DrosophilaTF 1.1), P07247 (JASPAR 2024) |
| Names: | KRUP_DROME |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P07247 |
| Length: | 502 |
| Pfam Domains: | 222-244 Zinc finger, C2H2 type 222-244 C2H2-type zinc finger 237-261 Zinc-finger double domain 250-272 Zinc finger, C2H2 type 250-272 C2H2-type zinc finger 264-288 Zinc-finger double domain 278-300 Zinc finger, C2H2 type 278-300 C2H2-type zinc finger 292-316 Zinc-finger double domain 306-328 Zinc finger, C2H2 type 306-325 Zinc-finger of C2H2 type 306-329 C2H2-type zinc finger 321-344 Zinc-finger double domain |
| Sequence: (in bold interface residues) | 1 MSISMLQDAQTRTLAAALAGIKQEDVHLDRSMSLSPPMSANTSATSAAAIYPAMGLQQAA 60 61 AASAFGMLSPTQLLAANRQAAAFMAQLPMSTLANTLFPHNPAALFGAWAAQQSLPPQGTH 120 121 LHSPPASPHSPLSTPLGSGKHPLNSPNSTPQHHEPAKKARKLSVKKEFQTEISMSVNDMY 180 181 HTSGGPISPPSSGSSPNSTHDGAGGNAGCVGVSKDPSRDKSFTCKICSRSFGYKHVLQNH 240 241 ERTHTGEKPFECPECHKRFTRDHHLKTHMRLHTGEKPYHCSHCDRQFVQVANLRRHLRVH 300 301 TGERPYTCEICDGKFSDSNQLKSHMLVHNGEKPFECERCHMKFRRRHHLMNHKCGIQSPP 360 361 TPALSPAMSGDYPVAISAIAIEASTNRFAAMCATYGGSNESVDMEKATPEDDGPLDLSED 420 421 GASSVDGHCSNIARRKAQDIRRVFRLPPPQIPHVPSDMPEQTEPEDLSMHSPRSIGSHEQ 480 481 TDDIDLYDLDDAPASYMGHQQH |
| Interface Residues: | 202, 204, 220, 229, 232, 233, 234, 235, 236, 239, 250, 260, 261, 262, 263, 264, 266, 267, 269, 270, 271, 273, 288, 289, 290, 291, 292, 293, 294, 295, 296, 298, 303, 316, 317, 318, 319, 320, 321, 322, 323, 324, 345, 346, 347, 348, 350, 351, 368 |
| 3D-footprint Homologues: | 2xrz_B, 7w1m_H, 6jnm_A, 7y3l_A, 8cuc_F, 1tf3_A, 7n5w_A, 2gli_A, 6wmi_A, 5k5i_A, 5v3j_F, 2drp_D, 5ei9_F, 1tf6_A, 8h9h_G, 7eyi_G, 7ysf_A, 2i13_A, 7y3m_I, 6a57_A, 1ubd_C, 2kmk_A, 3uk3_C, 1llm_D, 5yj3_D, 1mey_C, 8ssq_A, 6ml4_A, 4x9j_A, 6blw_A, 5kkq_D, 8ssu_A, 1g2f_F, 5yel_A, 7txc_E, 5kl3_A, 6e94_A, 2jpa_A, 5und_A, 5k5l_F, 2wbs_A, 1f2i_J, 6u9q_A, 8gn3_A, 4m9v_C, 2lt7_A, 1yuj_A, 7yzb_A |
| Binding Motifs: | Kr AACGGGTTAA MA0452.2 ytyAACCCTTTyty MA0452.3 yAACCCTTT |
| Binding Sites: | MA0452.2.1 MA0452.2.10 MA0452.2.11 MA0452.2.12 MA0452.2.13 MA0452.2.14 MA0452.2.15 MA0452.2.16 MA0452.2.17 MA0452.2.18 MA0452.2.19 MA0452.2.2 MA0452.2.20 MA0452.2.3 MA0452.2.4 MA0452.2.5 MA0452.2.6 MA0452.2.7 MA0452.2.8 MA0452.2.9 MA0452.3.1 MA0452.3.10 MA0452.3.11 MA0452.3.12 MA0452.3.13 MA0452.3.14 MA0452.3.15 MA0452.3.16 MA0452.3.17 MA0452.3.18 MA0452.3.19 MA0452.3.2 MA0452.3.20 MA0452.3.3 MA0452.3.4 MA0452.3.5 MA0452.3.6 MA0452.3.7 MA0452.3.8 MA0452.3.9 |
| Publications: | Stanojevic D., Hoey T., Levine M. Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krueppel in Drosophila. Nature 341:331-335 (1989). [Pubmed] Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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