Transcription Factor
| Accessions: | STA5B_MOUSE (HOCOMOCO 10), P42232 (JASPAR 2024) |
| Names: | STA5B_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P42232 |
| Length: | 786 |
| Pfam Domains: | 2-125 STAT protein, protein interaction domain 138-330 STAT protein, all-alpha domain 332-583 STAT protein, DNA binding domain 595-667 SH2 domain |
| Sequence: (in bold interface residues) | 1 MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWDSIDLDNPQENIKATQL 60 61 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQSTYDRCPMELVRCIRHILYNEQRLV 120 121 REANNGSSPAGSLADAMSQKHLQINQTFEELRLITQDTENELKKLQQTQEYFIIQYQESL 180 181 RIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLL 240 241 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC 300 301 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL 360 361 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS 420 421 LKRIKRSDRRGAESVTEEKFTILFDSQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA 480 481 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNI 540 541 SSNHLEDYNSMSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK 600 601 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL 660 661 GDLNYLIYVFPDRPKDEVYSKYYTPVPCEPATAKAADGYVKPQIKQVVPEFANASTDAGS 720 721 GATYMDQAPSPVVCPQAHYNMYPPNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQW 780 781 IPHAQS |
| Interface Residues: | 343, 433, 470, 471, 472, 473, 474 |
| 3D-footprint Homologues: | 1bf5_A, 4y5w_B, 1bg1_A |
| Binding Motifs: | MA0519.1 rtTTCCmRGAA STA5B_MOUSE.H10MO.C|M01364 rtTTCykrGAA MA1625.1 yawTTCCcAGAArts MA0519.2 TTCCmRGAA MA1625.2 TTCCcAGAA |
| Binding Sites: | MA1625.2.17 / MA1625.2.3 / MA1625.2.4 MA1625.2.10 / MA1625.2.12 / MA1625.2.15 / MA1625.2.18 / MA1625.2.19 / MA1625.2.9 MA0519.1.1 MA0519.1.10 MA0519.1.11 MA0519.1.12 MA0519.1.13 / MA0519.1.6 MA0519.1.14 MA0519.1.15 MA0519.1.16 MA0519.1.17 MA0519.1.18 MA0519.1.19 MA0519.1.2 MA0519.1.20 MA0519.1.3 MA0519.1.4 MA0519.1.5 MA0519.1.7 MA0519.1.8 MA0519.1.9 MA1625.2.13 / MA1625.2.14 / MA1625.2.16 MA1625.1.1 MA1625.1.10 / MA1625.1.8 MA1625.1.11 MA1625.1.12 / MA1625.1.9 MA1625.1.13 MA1625.1.14 MA1625.1.15 MA1625.1.10 / MA1625.1.16 MA1625.1.17 MA1625.1.18 MA1625.1.11 / MA1625.1.19 MA1625.1.2 MA1625.1.12 / MA1625.1.20 MA1625.1.3 MA1625.1.4 MA1625.1.4 / MA1625.1.5 MA1625.1.5 / MA1625.1.6 MA1625.1.7 MA1625.1.6 / MA1625.1.8 MA1625.1.7 / MA1625.1.9 MA1625.1.13 MA1625.1.14 MA1625.1.15 MA1625.1.16 MA1625.1.17 MA1625.1.18 MA1625.1.19 MA1625.1.20 MA0519.2.1 MA0519.2.10 MA0519.2.11 MA0519.2.12 MA0519.2.13 / MA0519.2.6 MA0519.2.14 MA0519.2.15 MA0519.2.16 MA0519.2.17 MA0519.2.18 MA0519.2.19 MA0519.2.2 MA0519.2.20 MA0519.2.3 MA0519.2.4 MA0519.2.5 MA0519.2.7 MA0519.2.8 MA0519.2.9 MA1625.2.8 MA1625.2.5 MA1625.2.1 / MA1625.2.11 / MA1625.2.7 MA1625.2.2 / MA1625.2.20 MA1625.2.6 |
| Publications: | Soldaini E., John S., Moro S., Bollenbacher J., Schindler U., Leonard W. J. DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.. Mol. Cell. Biol. 20:389-401 (2000). [Pubmed] Zhang Y, Laz E.V, Waxman D.J. Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver. Molecular and cellular biology 32:880-96 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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