Transcription Factor

Accessions: T161920_1.02 (CISBP 1.02), Q06595 (JASPAR 2024)
Names: T161920_1.02;, YPR196W, YP196_YEAST
Organisms: Saccharomyces cerevisiae
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:Zinc cluster
Length: 470
Pfam Domains: 6-42 Fungal Zn(2)-Cys(6) binuclear cluster domain
87-354 Fungal specific transcription factor domain
Sequence:
(in bold interface residues)
1 MSIVRQSCDCCRVRRVKCDRNRPCDRCRQRNLRCTYLQPLRKRGPKSIGESNLERAAEIQ 60
61 MVTVNNNIMAAPVMYKKVPKKVIDQCLRLYHDQLYVIWPMLSYDDLYKLLEENYEDCSTY 120
121 WFLVSLSAATLSDLHTKIEYKKGFFFAGEQLCNLCMSSRRFFDDLSNSDIFRIMTYYCLH 180
181 RCYAQFADTRTSYRLSCEAIGLIKIAGFHREETYEFLPFGEQQLIRKVYYLLLMTERYYA 240
241 VYIKCVTSLDTTISPPQPEIVTDSRLSLDSFLEVIKVFTVPGKYFYDALATNSVNGSYTE 300
301 DSLKRIWNELHISSLDIEPYSYGYIDYLFSRHWVRTLAWKLVLNKKDMRMNFFSNTNATH 360
361 IPVEIAKDMLQDTLLTPIDLYDVHGPVIPMKALEIANALVDVVSKYDHNMKLEAWNILCD 420
421 VSKFVFSLKHCNHKMFQRFSTKCQSALIDLPISRPLRLNDDSKDEVDIIP
Interface Residues: 12, 14, 15, 16, 17, 29, 30, 41, 43
3D-footprint Homologues: 1f5e_P, 1hwt_C, 1pyi_A, 6o19_A, 1zme_D, 7uik_T, 3coq_A, 6gys_C, 1d66_B
Binding Motifs: M1834_1.02 rwTtyyCCGa
MA0437.1 rWTTyyCCG
Publications: Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed]
Related annotations: PaperBLAST

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