Transcription Factor
| Accessions: | oc (DrosophilaTF 1.1), P22810 (JASPAR 2024) |
| Names: | HMOC_DROME, Homeotic protein ocelliless, Protein orthodenticle |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P22810 |
| Length: | 542 |
| Pfam Domains: | 68-124 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MAAGFLKSGDLGPHPHSYGGPHPHHSVPHGPLPPGMPMPSLGPFGLPHGLEAVGFSQGMW 60 61 GVNTRKQRRERTTFTRAQLDVLEALFGKTRYPDIFMREEVALKINLPESRVQVWFKNRRA 120 121 KCRQQLQQQQQSNSLSSSKNASGGGSGNSCSSSSANSRSNSNNNGSSSNNNTQSSGGNNS 180 181 NKSSQKQGNSQSSQQGGGSSGGNNSNNNSAAAAASAAAAVAAAQSIKTHHSSFLSAAAAA 240 241 ASGGTNQSANNNSNNNNQGNSTPNSSSSGGGGGSQAGGHLSAAAAAAALNVTAAHQNSSP 300 301 LLPTPATSVSPVSIVCKKEHLSGGYGSSVGGGGGGGGASSGGLNLGVGVGVGVGVGVGVS 360 361 QDLLRSPYDQLKDAGGDIGAGVHHHHSIYGSAAGSNPRLLQPGGNITPMDSSSSITTPSP 420 421 PITPMSPQSAAAAAHAAQSAQSAHHSAAHSAAYMSNHDSYNFWHNQYQQYPNNYAQAPSY 480 481 YSQMEYFSNQNQVNYNMGHSGYTASNFGLSPSPSFTGTVSAQAFSQNSLDYMSPQDKYAN 540 541 MV |
| Interface Residues: | 67, 68, 69, 70, 71, 109, 110, 112, 113, 116, 117, 120, 121, 124, 422, 457 |
| 3D-footprint Homologues: | 4j19_B, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 1puf_A, 6a8r_A, 3cmy_A, 2h1k_B, 2lkx_A, 1zq3_P, 1nk2_P, 6m3d_C, 1jgg_B, 3lnq_A, 6es3_K, 7q3o_C, 2ld5_A, 3rkq_B, 4xrs_G, 2hdd_A, 1b72_A, 4cyc_A, 2r5y_A, 2d5v_B, 5flv_I, 3l1p_A, 2hos_A, 5zjt_E, 3a01_E, 5hod_A, 1puf_B, 7psx_B, 1au7_A, 5jlw_D, 1e3o_C, 1le8_A, 8g87_X, 1du0_A, 6wig_A, 4qtr_D, 2g1p_A |
| Binding Motifs: | MA0234.1 TAATCC oc mcsyTAATCCsyt |
| Binding Sites: | MA0234.1.1 MA0234.1.10 MA0234.1.11 MA0234.1.12 MA0234.1.13 MA0234.1.14 MA0234.1.15 MA0234.1.16 MA0234.1.17 MA0234.1.18 MA0234.1.19 MA0234.1.2 MA0234.1.20 MA0234.1.3 MA0234.1.4 MA0234.1.5 MA0234.1.6 MA0234.1.7 MA0234.1.8 MA0234.1.9 |
| Publications: | Wilson D.S, Sheng G, Jun S, Desplan C. Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis. Proceedings of the National Academy of Sciences of the United States of America 93:6886-91 (1996). [Pubmed] Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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