Transcription Factor
| Accessions: | HIF1A_HUMAN (HOCOMOCO 10), Q16665 (JASPAR 2024) |
| Names: | ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, bHLHe78, Class E basic helix-loop-helix protein 78, HIF-1-alpha, HIF1-alpha, HIF1A_HUMAN, Hypoxia-inducible factor 1-alpha, Member of PAS protein 1, PAS domain-containing protein 8 |
| Organisms: | Homo sapiens, Oryctolagus cuniculus, Rattus rattus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 826 |
| Pfam Domains: | 94-150 PAS fold 249-337 PAS domain 251-328 PAS fold 254-339 PAS fold 550-582 Hypoxia-inducible factor-1 787-826 HIF-1 alpha C terminal transactivation domain |
| Sequence: (in bold interface residues) | 1 MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 60 61 RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120 121 GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR 180 181 TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK 240 241 TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV 300 301 TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV 360 361 LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET 420 421 DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP 480 481 NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF 540 541 AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT 600 601 VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR 660 661 DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR 720 721 KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC 780 781 RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN |
| Interface Residues: | 18, 19, 22, 23, 25, 26, 28, 29, 30 |
| 3D-footprint Homologues: | 5v0l_A, 4zpr_B, 1a0a_B, 7xhv_B, 7xi3_A, 4zpk_A, 5sy7_B, 7xi3_B, 4zpk_B, 5nj8_C, 4h10_A |
| Binding Motifs: | MA0259.1 vbACGTGc HIF1A_HUMAN.H10MO.A|M01211 ssstACGTGcss MA1106.1 gbACGTGCss MA0259.2 ACGTG MA1106.2 ACGTGC |
| Binding Sites: | MA0259.1.1 MA0259.1.10 MA0259.1.11 MA0259.1.12 MA0259.1.13 MA0259.1.14 MA0259.1.15 MA0259.1.16 MA0259.1.17 MA0259.1.18 MA0259.1.19 MA0259.1.2 MA0259.1.20 MA0259.1.3 MA0259.1.4 MA0259.1.5 MA0259.1.6 MA0259.1.7 MA0259.1.8 MA0259.1.9 MA1106.1.1 MA1106.1.10 MA1106.1.11 MA1106.1.12 MA1106.1.13 MA1106.1.14 MA1106.1.15 MA1106.1.16 MA1106.1.17 MA1106.1.18 / MA1106.1.4 MA1106.1.19 MA1106.1.2 MA1106.1.20 MA1106.1.3 MA1106.1.5 MA1106.1.6 MA1106.1.7 MA1106.1.8 MA1106.1.9 MA0259.2.1 / MA0259.2.10 MA0259.2.11 / MA0259.2.4 / MA0259.2.5 / MA0259.2.8 / MA0259.2.9 MA0259.2.12 MA0259.2.13 / MA0259.2.16 MA0259.2.14 / MA0259.2.18 MA0259.2.15 MA0259.2.17 / MA0259.2.20 MA0259.2.19 MA0259.2.2 / MA0259.2.3 MA0259.2.6 MA0259.2.7 MA1106.2.1 / MA1106.2.12 / MA1106.2.13 / MA1106.2.14 / MA1106.2.15 / MA1106.2.16 / MA1106.2.19 / MA1106.2.20 / MA1106.2.3 / MA1106.2.5 / MA1106.2.6 / MA1106.2.7 / MA1106.2.8 / MA1106.2.9 MA1106.2.10 / MA1106.2.17 / MA1106.2.2 MA1106.2.11 / MA1106.2.18 / MA1106.2.4 |
| Publications: | Wenger R.H, Stiehl D.P, Camenisch G. Integration of oxygen signaling at the consensus HRE. Science's STKE : signal transduction knowledge environment 2005:re12 (2005). [Pubmed] Ortiz-Barahona A, Villar D, Pescador N, Amigo J, del Peso L. Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction. Nucleic Acids Res 38:2332-45 (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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