Transcription Factor

						

			
Accessions: P63_HUMAN (HOCOMOCO 10), Q9H3D4 (JASPAR 2024)

			
Names: Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, p40, p51, P63_HUMAN, p73L, TP63, Transformation-related protein 63, Tumor protein 63, Tumor protein p73-like
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 680
Pfam Domains:   164-358 P53 DNA-binding domain
  391-431 P53 tetramerisation motif
  541-604 SAM domain (Sterile alpha motif)
Sequence: 
(in bold interface residues)		   1 MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWD   60
  61 FLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSM  120
 121 DQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS  180
 181 FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEV  240
 241 VKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFT  300
 301 TVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR  360
 361 KQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKES  420
 421 LELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQ  480
 481 LINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPP  540
 541 PPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKG  600
 601 ILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWND  660
 661 FNFDMDARRNKQQRIKEEGE
Interface Residues: 188, 189, 318, 346, 347, 350, 351
3D-footprint Homologues: 7xzz_N, 7xzx_N, 3q05_B, 5kbd_B, 3exj_A, 3qyn_C
Binding Motifs: MA0525.2 rACATGTygkrACATGTc
MA0525.1 agrCawGyyCarrCwTGyyy
P63_HUMAN.H10MO.A|M01413 rgrCAwGyctGgrCwTGyy
Binding Sites: MA0525.1.1
MA0525.1.10
MA0525.1.11
MA0525.1.12
MA0525.1.13
MA0525.1.14
MA0525.1.15
MA0525.1.16
MA0525.1.17
MA0525.1.18
MA0525.1.19
MA0525.1.2
MA0525.1.20
MA0525.1.3
MA0525.1.4
MA0525.1.5
MA0525.1.6
MA0525.1.7
MA0525.1.8
MA0525.1.9
			
Publications: Yang A, Zhu Z, Kapranov P, McKeon F, Church G.M, Gingeras T.R, Struhl K. Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Molecular cell 24:593-602 (2006). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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