Transcription Factor

						

			
Accessions: P41212 (JASPAR 2024)

			
Names: ETS translocation variant 6, ETS-related protein Tel1, ETV6_HUMAN, Transcription factor ETV6
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 452
Pfam Domains:    40-123 Sterile alpha motif (SAM)/Pointed domain
  340-421 Ets-domain
Sequence: 
(in bold interface residues)		   1 MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIY   60
  61 WSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHI  120
 121 LKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH  180
 181 RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPM  240
 241 ENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHRE  300
 301 GKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRW  360
 361 EDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFM  420
 421 KTPDEIMSGRTDRLEHLESQELDEQIYQEDEC
Interface Residues: 392, 393, 395, 396, 397, 399, 400, 414
3D-footprint Homologues: 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B
Binding Motifs: MA0645.1 msCGGAAGTr
MA0645.2 sCGGAAGTr
			
Publications: Green SM, Coyne HJ 3rd, McIntosh LP, Graves BJ. DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association. J Biol Chem 285:18496-504 (2010). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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