Transcription Factor
| Accessions: | Q9STM3 (JASPAR 2024) |
| Names: | EC 1.14.11.-, Jumonji domain-containing protein 12, Lysine-specific demethylase REF6, Lysine-specific histone demethylase REF6, Protein RELATIVE OF EARLY FLOWERING 6, REF6_ARATH |
| Organisms: | Arabidopsis thaliana |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9STM3 |
| Length: | 1360 |
| Pfam Domains: | 21-54 jmjN domain 233-352 JmjC domain, hydroxylase 1267-1290 C2H2-type zinc finger 1268-1290 Zinc finger, C2H2 type 1314-1337 Zinc-finger double domain |
| Sequence: (in bold interface residues) | 1 MAVSEQSQDVFPWLKSLPVAPEFRPTLAEFQDPIAYILKIEEEASRYGICKILPPLPPPS 60 61 KKTSISNLNRSLAARAAARVRDGGFGACDYDGGPTFATRQQQIGFCPRKQRPVQRPVWQS 120 121 GEEYSFGEFEFKAKNFEKNYLKKCGKKSQLSALEIETLYWRATVDKPFSVEYANDMPGSA 180 181 FIPLSLAAARRRESGGEGGTVGETAWNMRAMSRAEGSLLKFMKEEIPGVTSPMVYVAMMF 240 241 SWFAWHVEDHDLHSLNYLHMGAGKTWYGVPKDAALAFEEVVRVHGYGEELNPLVTFSTLG 300 301 EKTTVMSPEVFVKAGIPCCRLVQNPGEFVVTFPGAYHSGFSHGFNFGEASNIATPEWLRM 360 361 AKDAAIRRAAINYPPMVSHLQLLYDFVLALGSRVPTSINPKPRSSRLKDKARSEGERLTK 420 421 KLFVQNIIHNNELLSSLGKGSPVALLPQSSSDISVCSDLRIGSHLITNQENPIQLKCEDL 480 481 SSDSVVVDLSNGLKDTVSVKEKFTSLCERSRNHLASTEKDTQETLSDAERRKNDAAVALS 540 541 DQRLFSCVTCGVLSFDCVAIVQPKEAAARYLMSADCSFFNDWTAASGSANLGQAARSLHP 600 601 QSKEKHDVNYFYNVPVQTMDHSVKTGDQKTSTTSPTIAHKDNDVLGMLASAYGDSSDSEE 660 661 EDQKGLVTPSSKGETKTYDQEGSDGHEEARDGRTSDFNCQRLTSEQNGLSKGGKSSLLEI 720 721 ALPFIPRSDDDSCRLHVFCLEHAAEVEQQLRPFGGINLMLLCHPEYPRIEAEAKIVAEEL 780 781 VINHEWNDTEFRNVTREDEETIQAALDNVEAKGGNSDWTVKLGVNLSYSAILSRSPLYSK 840 841 QMPYNSIIYKAFGRSSPVASSPSKPKVSGKRSSRQRKYVVGKWCGKVWMSHQVHPFLLEQ 900 901 DLEGEESERSCHLRVAMDEDATGKRSFPNNVSRDSTTMFGRKYCRKRKIRAKAVPRKKLT 960 961 SFKREDGVSDDTSEDHSYKQQWRASGNEEESYFETGNTASGDSSNQMSDPHKGIIRHKGY 1020 1021 KEFESDDEVSDRSLGEEYTVRACAASESSMENGSQHSMYDHDDDDDDIDRQPRGIPRSQQ 1080 1081 TRVFRNPVSYESEDNGVYQQSGRISISNRQANRMVGEYDSAENSLEERGFCSTGKRQTRS 1140 1141 TAKRIAKTKTVQSSRDTKGRFLQEFASGKKNEELDSYMEGPSTRLRVRHQKPSRGSLETK 1200 1201 PKKIGKKRSGNASFSRVATEKDVEEKEEEEEEEENEEEECAAYQCNMEGCTMSFSSEKQL 1260 1261 MLHKRNICPIKGCGKNFFSHKYLVQHQRVHSDDRPLKCPWKGCKMTFKWAWSRTEHIRVH 1320 1321 TGARPYVCAEPDCGQTFRFVSDFSRHKRKTGHSVKKTNKR |
| Interface Residues: | 1256, 1258, 1259, 1261, 1262, 1264, 1265, 1266, 1278, 1279, 1280, 1281, 1282, 1284, 1285, 1289, 1307, 1308, 1309, 1310, 1311, 1312, 1314, 1315, 1316, 1319, 1338, 1339, 1340, 1341, 1342, 1343, 1344, 1345, 1346 |
| 3D-footprint Homologues: | 6ml4_A, 6wmi_A, 2i13_A, 1tf6_A, 5ei9_F, 1ubd_C, 6e94_A, 2jpa_A, 7y3l_A, 3uk3_C, 7n5w_A, 1tf3_A, 6jnm_A, 8cuc_F, 6blw_A, 5kkq_D, 2kmk_A, 1mey_C, 6u9q_A, 1f2i_J, 7txc_E, 5kl3_A, 7ysf_A, 4x9j_A, 1g2f_F, 7eyi_G, 5v3j_F, 2gli_A, 8h9h_G, 2lt7_A, 6a57_A, 7w1m_H, 5und_A, 1llm_D, 8gn3_A, 5yel_A, 8ssq_A, 2wbs_A, 4m9v_C, 7y3m_I, 5yj3_D |
| Binding Motifs: | MA1415.1 rAAACAGAGya MA1415.2 rAAACAGAG |
| Publications: | Li C, Gu L, Gao L, Chen C, Wei CQ, Qiu Q, Chien CW, Wang S, Jiang L, Ai LF, Chen CY, Yang S, Nguyen V, Qi Y, Snyder MP, Burlingame AL, Kohalmi SE, Huang S, Cao X, Wang ZY, Wu K, Chen X, Cui Y. Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis. Nat Genet 48:687-93 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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