Transcription Factor
| Accessions: | P78545 (JASPAR 2024) |
| Names: | E74-like factor 3, ELF3_HUMAN, Epithelial-restricted with serine box, Epithelium-restricted Ets protein ESX, Epithelium-specific Ets transcription factor 1, ESE-1, ETS-related transcription factor Elf-3 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 371 |
| Pfam Domains: | 49-131 Sterile alpha motif (SAM)/Pointed domain 273-356 Ets-domain |
| Sequence: (in bold interface residues) | 1 MAATCEISNIFSNYFSAMYSSEDSTLASVPPAATFGADDLVLTLSNPQMSLEGTEKASWL 60 61 GEQPQFWSKTQVLDWISYQVEKNKYDASAIDFSRCDMDGATLCNCALEELRLVFGPLGDQ 120 121 LHAQLRDLTSSSSDELSWIIELLEKDGMAFQEALDPGPFDQGSPFAQELLDDGQQASPYH 180 181 PGSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDPTDGKLFPSDGFRDCKKGDP 240 241 KHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLWEFIRDILIHPELNEGLMKWENRHE 300 301 GVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNSSG 360 361 WKEEEVLQSRN |
| Interface Residues: | 327, 328, 330, 331, 332, 334, 335, 349 |
| 3D-footprint Homologues: | 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A |
| Binding Motifs: | MA0640.1 wACCCGGAAGTrr MA0640.2 yyccACTTCCTgbt MA0640.3 cACTTCCTg |
| Binding Sites: | MA0640.2.1 MA0640.2.10 / MA0640.2.8 MA0640.2.11 / MA0640.2.9 MA0640.2.10 / MA0640.2.12 MA0640.2.11 / MA0640.2.13 MA0640.2.12 / MA0640.2.14 MA0640.2.13 / MA0640.2.15 MA0640.2.16 MA0640.2.14 / MA0640.2.17 MA0640.2.18 MA0640.2.15 / MA0640.2.19 MA0640.2.1 / MA0640.2.2 MA0640.2.16 / MA0640.2.20 MA0640.2.3 MA0640.2.2 / MA0640.2.4 MA0640.2.3 / MA0640.2.5 MA0640.2.4 / MA0640.2.6 MA0640.2.5 / MA0640.2.7 MA0640.2.6 / MA0640.2.8 MA0640.2.7 / MA0640.2.9 MA0640.2.17 MA0640.2.18 MA0640.2.19 MA0640.2.20 MA0640.3.15 MA0640.3.1 MA0640.3.2 / MA0640.3.4 / MA0640.3.8 MA0640.3.10 MA0640.3.11 MA0640.3.12 MA0640.3.13 MA0640.3.14 / MA0640.3.3 MA0640.3.16 MA0640.3.17 MA0640.3.18 MA0640.3.19 / MA0640.3.6 MA0640.3.20 MA0640.3.5 MA0640.3.7 MA0640.3.9 |
| Publications: | Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] Oettgen P., Alani R. M., Barcinski M. A., Brown L., Akbarali Y., Boltax J., Kunsch C., Munger K., Libermann T. A. Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family.. Mol. Cell. Biol. 17:4419-4433 (1997). [Pubmed] |
| Related annotations: | PaperBLAST |
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