Transcription Factor

Accessions: CRX (HT-SELEX2 May2017)
Names: CRX, ENSG00000105392
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 326
Pfam Domains: 46-99 Homeobox domain
Sequence:
(in bold interface residues)
1 MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSPPLALDPPRRQRQERTVYTESQQKVL 60
61 EFYFQKDQYPNYDQRLNLAEMLSLREQQLQVWFKNRRAKLARERRLQQQPQRVPGQRGRG 120
121 ARAAPLVPVAAASFPGGPEFPQGRGSWISPQPGPWGVLPAAEPKIYSLPRTWGGPECGTQ 180
181 EGLKAVPAPGPGPIPAPIPGPAQIPGPVPGPAPNLGPMSGPLSVSIPGPIPAPISCPGPI 240
241 PDPVLGRTLMPGPGSLPTPAPGALWPQSPYASNLSPDTQLYPDFTKLLPLLDRFEESSLS 300
301 TTTSQYKEEDGFVDKNHSVPRSLLDL
Interface Residues: 45, 46, 47, 48, 49, 87, 88, 90, 91, 94, 95, 98, 99, 101, 102
3D-footprint Homologues: 4j19_B, 3a01_E, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 2lkx_A, 1nk2_P, 1zq3_P, 7q3o_C, 6es3_K, 2ld5_A, 1jgg_B, 7psx_B, 5hod_A, 3lnq_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 6m3d_C, 5flv_I, 5zjt_E, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 4qtr_D, 3l1p_A, 1o4x_A, 1du0_A
Binding Motifs: CRX_2 cTAATCCs
CRX_methyl_1 cTAATCCc
Related annotations: PaperBLAST

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