Transcription Factor
| Accessions: | RFX5_HUMAN (HOCOMOCO 10), P48382 (JASPAR 2024) |
| Names: | DNA-binding protein RFX5, Regulatory factor X 5, RFX5_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P48382 |
| Length: | 616 |
| Pfam Domains: | 86-158 RFX DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MAEDEPDAKSPKTGGRAPPGGAEAGEPTTLLQRLRGTISKAVQNKVEGILQDVQKFSDND 60 61 KLYLYLQLPSGPTTGDKSSEPSTLSNEEYMYAYRWIRNHLEEHTDTCLPKQSVYDAYRKY 120 121 CESLACCRPLSTANFGKIIREIFPDIKARRLGGRGQSKYCYSGIRRKTLVSMPPLPGLDL 180 181 KGSESPEMGPEVTPAPRDELVEAACALTCDWAERILKRSFSSIVEVARFLLQQHLISARS 240 241 AHAHVLKAMGLAEEDEHAPRERSSKPKNGLENPEGGAHKKPERLAQPPKDLEARTGAGPL 300 301 ARGERKKSVVESSAPGANNLQVNALVARLPLLLPRAPRSLIPPIPVSPPILAPRLSSGAL 360 361 KVATLPLSSRAGAPPAAVPIINMILPTVPALPGPGPGPGRAPPGGLTQPRGTENREVGIG 420 421 GDQGPHDKGVKRTAEVPVSEASGQAPPAKAAKQDIEDTASDAKRKRGRPRKKSGGSGERN 480 481 STPLKSAAAMESAQSSRLPWETWGSGGEGNSAGGAERPGPMGEAEKGAVLAQGQGDGTVS 540 541 KGGRGPGSQHTKEAEDKIPLVPSKVSVIKGSRSQKEAFPLAKGEVDTAPQGNKDLKEHVL 600 601 QSSLSQEHKDPKATPP |
| Interface Residues: | 133, 137, 150, 154, 159 |
| 3D-footprint Homologues: | 1dp7_P |
| Binding Motifs: | MA0510.2 sGTTrCYATGGyAACs MA0510.1 ytsCmTrGCAACwgs RFX5_HUMAN.H10MO.A|M01485 stcmbcwGTtgCyrgGsara MA0510.3 GTTrCYATGGyAAC |
| Binding Sites: | MA0510.1.1 MA0510.1.10 MA0510.1.11 MA0510.1.12 MA0510.1.13 MA0510.1.14 MA0510.1.15 MA0510.1.16 MA0510.1.17 MA0510.1.18 MA0510.1.19 MA0510.1.2 MA0510.1.20 MA0510.1.3 MA0510.1.4 MA0510.1.5 MA0510.1.6 MA0510.1.7 MA0510.1.8 MA0510.1.9 |
| Publications: | Emery P., Strubin M., Hofmann K., Bucher P., Mach B., Reith W. A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol. Cell. Biol. 16:4486-4494 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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