Transcription Factor
Accessions: | BHLHB3_full (HumanTF 1.0) |
Names: | BHE41_HUMAN, BHLHB3, bHLHe41, Class B basic helix-loop-helix protein 3, Class E basic helix-loop-helix protein 41, Differentially expressed in chondrocytes protein 2, Enhancer-of-split and hairy-related protein 1, hDEC2, SHARP-1 |
Organisms: | Homo sapiens |
Libraries: | HumanTF 1.0 1 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
Uniprot: | Q9C0J9 |
Notes: | Ensembl ID: ENSG00000123095; Full protein sequence; TF family: bHLH; Clone source: Megaman |
Length: | 483 |
Pfam Domains: | 49-99 Helix-loop-helix DNA-binding domain 130-172 Hairy Orange |
Sequence: (in bold interface residues) | 1 MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSMKRDDTKDTYKLPHRLIEKKRRDRI 60 61 NECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSL 120 121 KSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHLHAVATQFLPTPQLL 180 181 TQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAAENDTDTDS 240 241 GYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAA 300 301 AAALLGPDPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSAAA 360 361 AYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSSVLS 420 421 PPPEKAGAAAATLLPHEVAPLGAPHPQHPHGRTHLPFAGPREPGNPESSAQEDPSQPGKE 480 481 AP* |
Interface Residues: | 49, 50, 52, 53, 56, 57, 83, 85 |
3D-footprint Homologues: | 7rcu_E, 5i50_B, 6g1l_A, 7ssa_L, 1am9_A, 7d8t_A, 4zpk_A, 7xi3_A, 5nj8_D, 7f2f_B, 5eyo_A, 5v0l_A, 4h10_A, 8osl_P, 1an4_A, 4h10_B, 8osl_O, 5nj8_C |
Binding Motifs: | BHLHB3_full skCACGTGmc |
Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.