Transcription Factor

Accessions: BHLHB3_full (HumanTF 1.0)
Names: BHE41_HUMAN, BHLHB3, bHLHe41, Class B basic helix-loop-helix protein 3, Class E basic helix-loop-helix protein 41, Differentially expressed in chondrocytes protein 2, Enhancer-of-split and hairy-related protein 1, hDEC2, SHARP-1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q9C0J9
Notes: Ensembl ID: ENSG00000123095; Full protein sequence; TF family: bHLH; Clone source: Megaman
Length: 483
Pfam Domains: 49-99 Helix-loop-helix DNA-binding domain
130-172 Hairy Orange
Sequence:
(in bold interface residues)
1 MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSMKRDDTKDTYKLPHRLIEKKRRDRI 60
61 NECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSL 120
121 KSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHLHAVATQFLPTPQLL 180
181 TQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAAENDTDTDS 240
241 GYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAA 300
301 AAALLGPDPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSAAA 360
361 AYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSSVLS 420
421 PPPEKAGAAAATLLPHEVAPLGAPHPQHPHGRTHLPFAGPREPGNPESSAQEDPSQPGKE 480
481 AP*
Interface Residues: 49, 50, 52, 53, 56, 57, 83, 85
3D-footprint Homologues: 7rcu_E, 5i50_B, 6g1l_A, 7ssa_L, 1am9_A, 7d8t_A, 4zpk_A, 7xi3_A, 5nj8_D, 7f2f_B, 5eyo_A, 5v0l_A, 4h10_A, 8osl_P, 1an4_A, 4h10_B, 8osl_O, 5nj8_C
Binding Motifs: BHLHB3_full skCACGTGmc
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

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