Transcription Factor

Accessions: T061535_1.02 (CISBP 1.02), Q03833 (JASPAR 2024)
Names: GIS1, T061535_1.02;, GIS1_YEAST
Organisms: Saccharomyces cerevisiae
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:C2H2 ZF
Length: 894
Pfam Domains: 13-46 jmjN domain
192-307 JmjC domain, hydroxylase
828-851 C2H2-type zinc finger
842-868 Zinc-finger double domain
857-878 C2H2-type zinc finger
857-878 Zinc finger, C2H2 type
Sequence:
(in bold interface residues)
1 MEIKPVEVIDGVPVFKPSMMEFANFQYFIDEITKFGIENGIVKVIPPKEWLELLEGSPPA 60
61 ESLKTIQLDSPIQQQAKRWDKHENGVFSIENEYDNKSYNLTQWKNLAESLDSRISQGDFN 120
121 DKTLKENCRVDSQQDCYDLAQLQILESDFWKTIAFSKPFYAVDENSSIFPYDLTLWNLNN 180
181 LPDSINSSNRRLLTGQSKCIFPWHLDEQNKCSINYLHFGAPKQWYSIPSANTDQFLKILS 240
241 KEPSSNKENCPAFIRHQNIITSPDFLRKNNIKFNRVVQFQHEFIITFPYCMYSGFNYGYN 300
301 FGESIEFILDQQAVVRKQPLKCGCGNKKEERKSGPFSNLSYDSNESEQRGSITDNDNDLF 360
361 QKVRSFDELLNHSSQELQNLEDNKNPLFSNINMNRPQSSSLRSTTPNGVNQFLNMNQTTI 420
421 SRISSPLLSRMMDLSNIVEPTLDDPGSKFKRKVLTPQLPQMNIPSNSSNFGTPSLTNTNS 480
481 LLSNITATSTNPSTTTNGSQNHNNVNANGINTSAAASINNNISSTNNSANNSSSNNNVST 540
541 VPSSMMHSSTLNGTSGLGGDNDDNMLALSLATLANSATASPRLTLPPLSSPMNPNGHTSY 600
601 NGNMMNNNSGNGSNGSNSYSNGVTTAAATTTSAPHNLSIVSPNPTYSPNPLSLYLTNSKN 660
661 PLNSGLAPLSPSTSNIPFLKRNNVVTLNISREASKSPISSFVNDYRSPLGVSNPLMYSST 720
721 INDYSNGTGIRQNSNNINPLDAGPSFSPLHKKPKILNGNDNSNLDSNNFDYSFTGNKQES 780
781 NPSILNNNTNNNDNYRTSSMNNNGNNYQAHSSKFGENEVIMSDHGKIYICRECNRQFSSG 840
841 HHLTRHKKSVHSGEKPHSCPRCGKRFKRRDHVLQHLNKKIPCTQEMENTKLAES
Interface Residues: 802, 803, 805, 806, 808, 809, 811, 812, 813, 817, 818, 821, 837, 838, 839, 840, 841, 842, 843, 844, 845, 846, 849, 866, 867, 868, 869, 870, 871, 872, 873, 874, 875, 878, 893
3D-footprint Homologues: 1tf3_A, 6ml4_A, 2kmk_A, 5yel_A, 7w1m_H, 8cuc_F, 7y3l_A, 3uk3_C, 7n5w_A, 1g2f_F, 5kl3_A, 2wbs_A, 1ubd_C, 5ei9_F, 2jpa_A, 1mey_C, 5und_A, 2drp_D, 8gn3_A, 1f2i_J, 5k5i_A, 6u9q_A, 7txc_E, 6blw_A, 5kkq_D, 2lt7_A, 6wmi_A, 4x9j_A, 2i13_A, 8ssq_A, 1llm_D, 5v3j_F, 4m9v_C, 2gli_A, 8h9h_G, 6e94_A, 7eyi_G, 7y3m_I, 1tf6_A, 7ysf_A, 6a57_A, 5yj3_D
Binding Motifs: M0506_1.02 wwwwAGGGGt
MA0306.1 wCCCCTwww
MA0306.2 CCCCTw
Publications: Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.