Transcription Factor

						

			
Accessions: LHX6 (SMILE-seq 1.0)

			
Names: LHX6, LHX6_HUMAN, LIM homeobox protein 6, LIM/homeobox protein Lhx6, LIM/homeobox protein Lhx6.1
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: Q9UPM6
Notes: TF family: homeobox
Length: 362
Pfam Domains:    70-127 LIM domain
  131-185 LIM domain
  220-276 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGALDKDEGQASPCTPSTPSVCSPPSAAS   60
  61 SVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCK  120
 121 MDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVL  180
 181 CRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQ  240
 241 DNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAPPSRLPSALSDD  300
 301 IHYTPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADMDGPLSNRGEKVIL  360
 361 FQ
Interface Residues: 220, 221, 222, 223, 261, 262, 264, 265, 268, 269, 272, 273, 276
3D-footprint Homologues: 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 1fjl_B, 3d1n_M, 1ig7_A, 6a8r_A, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 1nk2_P, 1zq3_P, 7q3o_C, 6es3_K, 2ld5_A, 3a01_E, 5jlw_D, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 4cyc_A, 7psx_B, 5hod_A, 3l1p_A, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_B, 1o4x_A, 1du0_A, 4qtr_D
Binding Motifs: LHX6 ryTrATTR
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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