Transcription Factor
| Accessions: | SPI1_HUMAN (HOCOMOCO 10), P17947 (JASPAR 2024) |
| Names: | 31 kDa-transforming protein, SPI1_HUMAN, Transcription factor PU.1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P17947 |
| Length: | 270 |
| Pfam Domains: | 169-253 Ets-domain |
| Sequence: (in bold interface residues) | 1 MLQACKMEGFPLVPPPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVHS 60 61 EFESFAENNFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHPSLGHQVSYLPRMCLQ 120 121 YPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGETGSKKKIRLYQFLLDLL 180 181 RSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGE 240 241 VKKVKKKLTYQFSGEVLGRGGLAERRHPPH |
| Interface Residues: | 226, 227, 229, 230, 231, 233, 234, 247 |
| 3D-footprint Homologues: | 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C |
| Binding Motifs: | MA0080.2 AGGAAGT MA0080.4 aAAAAGmGGAAGTw SPI1_HUMAN.H10MO.A|M01529 rrAAAGrGGAASTGara MA0080.1 sGGAAs MA0080.5 rrraaAGAGGAAGTGAaarw |
| Binding Sites: | MA0080.1.1 MA0080.1.10 MA0080.1.11 MA0080.1.12 MA0080.1.13 MA0080.1.14 MA0080.1.15 MA0080.1.16 MA0080.1.17 MA0080.1.18 MA0080.1.19 MA0080.1.2 MA0080.1.20 MA0080.1.3 MA0080.1.4 MA0080.1.5 MA0080.1.6 MA0080.1.7 MA0080.1.8 MA0080.1.9 MA0080.2.1 MA0080.2.10 MA0080.2.11 MA0080.2.12 MA0080.2.13 MA0080.2.14 MA0080.2.15 MA0080.2.16 MA0080.2.17 MA0080.2.18 MA0080.2.19 MA0080.2.2 MA0080.2.20 MA0080.2.3 MA0080.2.4 MA0080.2.5 MA0080.2.6 MA0080.2.7 MA0080.2.8 MA0080.2.9 MA0080.5.1 MA0080.5.10 MA0080.5.11 MA0080.5.12 MA0080.5.13 MA0080.5.14 MA0080.5.15 MA0080.5.16 MA0080.5.17 MA0080.5.18 MA0080.5.19 MA0080.5.2 MA0080.5.20 MA0080.5.3 MA0080.5.4 MA0080.5.5 MA0080.5.6 MA0080.5.7 MA0080.5.8 MA0080.5.9 |
| Publications: | Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed] Ray-Gallet D, Mao C, Tavitian A, Moreau-Gachelin F. DNA binding specificities of Spi-1/PU.1 and Spi-B transcription factors and identification of a Spi-1/Spi-B binding site in the c-fes/c-fps promoter. Oncogene 11:303-13 (1995). [Pubmed] |
| Related annotations: | PaperBLAST |
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