Transcription Factor
| Accessions: | Q9UPM6 (JASPAR 2024) |
| Names: | LHX6_HUMAN, LIM homeobox protein 6, LIM/homeobox protein Lhx6, LIM/homeobox protein Lhx6.1 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9UPM6 |
| Length: | 363 |
| Pfam Domains: | 70-127 LIM domain 131-185 LIM domain 220-276 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGALDKDEGQASPCTPSTPSVCSPPSAAS 60 61 SVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCK 120 121 MDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVL 180 181 CRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQ 240 241 DNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAPPSRLPSALSDD 300 301 IHYTPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADMDGPLSNRGEKVIL 360 361 FQY |
| Interface Residues: | 220, 221, 222, 223, 261, 262, 264, 265, 268, 269, 272, 273, 276 |
| 3D-footprint Homologues: | 1puf_A, 3cmy_A, 5zfz_A, 1fjl_B, 3d1n_M, 1ig7_A, 6a8r_A, 2h1k_B, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 1nk2_P, 1zq3_P, 7q3o_C, 6es3_K, 2ld5_A, 5jlw_D, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 4cyc_A, 7psx_B, 5hod_A, 3l1p_A, 3a01_E, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_B, 1o4x_A, 1du0_A, 4qtr_D |
| Binding Motifs: | MA0658.1 rcTAATTAry MA0658.2 cTAATTAr |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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