Transcription Factor

						

			
Accessions: 1a02_N (3D-footprint 20231221), 1s9k_C (3D-footprint 20231221)

			
Names: NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, NUCLEAR FACTOR OF ACTIVATED T CELLS, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q13469
Length: 280
Pfam Domains:    12-172 Rel homology domain (RHD)
  191-277 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 WPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQI   60
  61 FIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGI  120
 121 LKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELP  180
 181 MVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNML  240
 241 FVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Interface Residues: 23, 25, 26, 28, 29, 32, 122, 139, 172, 173, 174, 203, 204, 236, 266, 267
3D-footprint Homologues: 1imh_C, 1p7h_L, 1a66_A, 2o61_A, 1nfk_A
Binding Motifs: 1a02_FJN GGAananwTGnyTCA
1s9k_CDE TGAAnAnnTGTGTAA
Binding Sites: 1a02_A
1a02_B
			
Publications: Chen L., Glover J. N. M., Hogan P. G., Rao A., Harrison S. C. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.. Nature 392:42-48 (1998). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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