Transcription Factor
| Accessions: | T093392_1.02 (CISBP 1.02), ALX1 (HT-SELEX2 May2017), ALX1_HUMAN (HOCOMOCO 10) |
| Names: | ALX1, T093392_1.02;, ENSG00000180318, ALX homeobox protein 1, ALX1_HUMAN, CART-1, Cartilage homeoprotein 1 |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, HT-SELEX2 May2017 2, HOCOMOCO 10 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 3 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] |
| Uniprot: | Q15699 |
| Notes: | family:Homeodomain, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 326 |
| Pfam Domains: | 133-189 Homeobox domain 302-321 OAR domain |
| Sequence: (in bold interface residues) | 1 MEFLSEKFALKSPPSKNSDFYMGAGGPLEHVMETLDNESFYSKASAGKCVQAFGPLPRAE 60 61 HHVRLERTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNSLRMSPVKGMQEKGELDELG 120 121 DKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWF 180 181 QNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCM 240 241 LPRDTSSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFTDSLLTGATNGHAFETKPE 300 301 FERRSSSIAVLRMKAKEHTANISWAM |
| Interface Residues: | 132, 133, 134, 135, 136, 174, 175, 177, 178, 181, 182, 185, 186, 189 |
| 3D-footprint Homologues: | 4j19_B, 3cmy_A, 6a8r_A, 3d1n_M, 1fjl_B, 5zfz_A, 2h1k_B, 1ig7_A, 1puf_A, 1jgg_B, 1zq3_P, 1nk2_P, 6m3d_C, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 5zjt_E, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 2hos_A, 5jlw_D, 4cyc_A, 4xrs_G, 3l1p_A, 1b72_A, 3a01_E, 5flv_I, 1e3o_C, 1le8_A, 2xsd_C, 7xrc_C, 1du0_A, 4qtr_D, 4xrm_B |
| Binding Motifs: | M3016_1.02 mvcTAATTmmhATTAbyd ALX1_2 TAATTARATTA ALX1_methyl_1 TAATTARATTA ALX1_HUMAN.H10MO.B|M01003 rTAATtrvATTA |
| Related annotations: | PaperBLAST |
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