Transcription Factor
| Accessions: | E2F1 (HT-SELEX2 May2017), E2F1_HUMAN (HOCOMOCO 10), NP_005216 (JASPAR 2024), Q01094 (JASPAR 2024) |
| Names: | E2F1, ENSG00000101412, E2F-1, E2F1_HUMAN, PBR3, pRB-binding protein E2F-1, RBAP-1, RBBP-3, Retinoblastoma-associated protein 1, Retinoblastoma-binding protein 3, Transcription factor E2F1 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: E2F experiment: HT-SELEX Hamming distance: 2 cycle: 4 |
| Length: | 437 |
| Pfam Domains: | 127-192 E2F/DP family winged-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCD 60 61 PDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVK 120 121 SPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLI 180 181 AKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDS 240 241 QRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPE 300 301 ETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLS 360 361 RMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEG 420 421 IRDLFDCDFGDLTPLDF |
| Interface Residues: | 127, 163, 164, 165, 166, 168 |
| 3D-footprint Homologues: | 1cf7_A, 4yo2_A, 1cf7_B |
| Binding Motifs: | MA0024.3 tttGGCGCCaaa MA0024.2 sgsGCGSSArv E2F1_1 rwTTTGGCGCCawwwy E2F1_HUMAN.H10MO.A|M01086 arwkGGCGsGAArr MA0024.1 TTTsGCGC |
| Binding Sites: | MA0024.1.2 / MA0024.1.3 / MA0024.1.4 MA0024.1.5 / MA0024.1.6 / MA0024.1.7 MA0024.1.8 MA0024.1.10 MA0024.1.9 MA0024.1.1 MA0024.2.1 MA0024.2.10 / MA0024.2.13 MA0024.2.11 MA0024.2.12 MA0024.2.14 MA0024.2.15 MA0024.2.16 MA0024.2.17 MA0024.2.18 MA0024.2.19 MA0024.2.2 MA0024.2.20 MA0024.2.3 MA0024.2.4 MA0024.2.5 MA0024.2.6 MA0024.2.7 MA0024.2.8 MA0024.2.9 |
| Publications: | Nevins R. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429 (1992). [Pubmed] Tao Y., Kassatly R. F., Cress W. D., Horowitz J. M. Subunit composition determines E2F DNA-binding site specificity. Mol. Cell. Biol. 17:6994-7007 (1997). [Pubmed] Xu X., Bieda M., Jin V. X., Rabinovich A., Oberley M. J., Green R., Farnham P. J. A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members.. Genome Res. 17:1550-1561 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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