Transcription Factor

						

			
Accessions: E2Fe (Athamap 20091028), T076545_1.02 (CISBP 1.02), T16084 (AthalianaCistrome v4_May2016), Q8LSZ4 (JASPAR 2024)

			
Names: DEL1, DP-E2F-like protein 1, E2F transcription factor-like E2FE, E2F-like repressor E2L3, E2Fe, E2L3, T076545_1.02;, AT3G48160, T16084;, E2FE_ARATH
Organisms: Arabidopsis thaliana
Libraries: Athamap 20091028 1, CISBP 1.02 2, AthalianaCistrome v4_May2016 3, JASPAR 2024 4
1 Bulow L, Engelmann S, Schindler M, Hehl R. AthaMap, integrating transcriptional and post-transcriptional data. Nucleic acids research 37:D983-6 (2009).  [Pubmed]

2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]

3 O'Malley RC, Huang SS, Song L, Lewsey MG, Bartlett A, Nery JR, Galli M, Gallavotti A, Ecker JR. Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape. Cell 165:1280-92 (2016). [Pubmed]

4 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q8LSZ4
Notes: experiment type:PBM, family:E2F, ecotype:Col-0, experiment type: ampDAP-seq, experiment type: ampDAP-seq (methyl-cytosines removed by PCR), experiment type: DAP-seq, family:E2F-DP
Length: 403
Pfam Domains:     34-99 E2F/DP family winged-helix DNA-binding domain
  169-250 E2F/DP family winged-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 MSDLSPERFKLAVTSPSSIPESSSALQLHHSYSRKQKSLGLLCTNFLALYNREGIEMVGL   60
  61 DDAASKLGVERRRIYDIVNVLESVGVLTRRAKNQYTWKGFSAIPGALKELQEEGVKDTFH  120
 121 RFYVNENVKGSDDEDDDEESSQPHSSSQTDSSKPGSLPQSSDPSKIDNRREKSLGLLTQN  180
 181 FIKLFICSEAIRIISLDDAAKLLLGDAHNTSIMRTKVRRLYDIANVLSSMNLIEKTHTLD  240
 241 SRKPAFKWLGYNGEPTFTLSSDLLQLESRKRAFGTDITNVNVKRSKSSSSSQENATERRL  300
 301 KMKKHSTPESSYNKSFDVHESRHGSRGGYHFGPFAPGTGTYPTAGLEDNSRRAFDVENLD  360
 361 SDYRPSYQNQVLKDLFSHYMDAWKTWFSEVTQENPLPNTSQHR
Interface Residues: 34, 70, 71, 72, 73, 75, 215, 218, 219, 221
3D-footprint Homologues: 4yo2_A, 1cf7_A, 2qby_A, 1cf7_B
Binding Motifs: E2Fe wTTCCCGC
M0665_1.02 tksGCGCsma
M0365 tTTTTGGCGGGAAAA
M0367 amwawawwTTTCCCGCCAAAA
MA1750.1 tTTTTGGCGGGAAAA
Binding Sites: E2Fe_1
E2Fe_2
E2Fe_3
			
Publications: Mariconti L, Pellegrini B, Cantoni R, Stevens R, Bergounioux C, Cella R, Albani D. 2002. The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants. J Biol Chem. 277:9911-9. [Pubmed]


 Egelkrout EM, Mariconti L, Settlage SB, Cella R, Robertson D, Hanley-Bowdoin L. 2002. Two E2F elements regulate the proliferating cell nuclear antigen promoter differently during leaf development. Plant Cell. 14:3225-36. [Pubmed]


Vandepoele K, Vlieghe K, Florquin K, Hennig L, Beemster GT, Gruissem W, Van de Peer Y, Inzé D, De Veylder L. Genome-wide identification of potential plant E2F target genes. Plant Physiol 139:316-28 (2005). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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