Transcription Factor

Accessions: Q13887 (JASPAR 2024)
Names: Basic transcription element-binding protein 2, BTE-binding protein 2, Colon krueppel-like factor, GC-box-binding protein 2, Intestinal-enriched krueppel-like factor, KLF5_HUMAN, Krueppel-like factor 5, Transcription factor BTEB2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q13887
Length: 457
Pfam Domains: 373-397 C2H2-type zinc finger
374-397 Zinc finger, C2H2 type
389-411 Zinc-finger double domain
403-427 C2H2-type zinc finger
403-427 Zinc finger, C2H2 type
420-444 Zinc-finger double domain
433-455 C2H2-type zinc finger
433-455 Zinc finger, C2H2 type
Sequence:
(in bold interface residues)
1 MATRVLSMSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAALFPGEELKHAHHRPQA 60
61 QPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLTPQLPPVPIIPEHKKYRRDSASVV 120
121 DQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPP 180
181 APTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMP 240
241 SSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVKQFQGMPPCTYTMPSQFLPQQATYF 300
301 PPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYN 360
361 RRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDEL 420
421 TRHYRKHTGAKPFQCGVCNRSFSRSDHLALHMKRHQN
Interface Residues: 320, 362, 365, 368, 369, 385, 386, 387, 388, 389, 391, 392, 394, 395, 398, 415, 416, 417, 418, 419, 421, 422, 423, 426, 443, 444, 445, 446, 447, 448, 449, 450, 451, 454
3D-footprint Homologues: 6mup_M, 5v3j_F, 5ei9_F, 7ysf_A, 6ml4_A, 7n5w_A, 3uk3_C, 1tf3_A, 6jnm_A, 8ssq_A, 1tf6_A, 7w1m_H, 2i13_A, 7eyi_G, 6blw_A, 5kkq_D, 8ssu_A, 1ubd_C, 1mey_C, 5kl3_A, 6u9q_A, 2kmk_A, 5und_A, 2gli_A, 1g2f_F, 6wmi_A, 8h9h_G, 2lt7_A, 6e94_A, 7y3m_I, 6a57_A, 2jpa_A, 5k5i_A, 8cuc_F, 7y3l_A, 4m9v_C, 5k5l_F, 4x9j_A, 1llm_D, 2wbs_A, 5yel_A, 8gn3_A, 2drp_D, 1f2i_J, 7txc_E, 5yj3_D
Binding Motifs: MA0599.1 gCCMCrCCCh
Binding Sites: MA0599.1.1
MA0599.1.10
MA0599.1.11
MA0599.1.12
MA0599.1.13
MA0599.1.14
MA0599.1.15
MA0599.1.16
MA0599.1.17
MA0599.1.18
MA0599.1.19
MA0599.1.2
MA0599.1.20
MA0599.1.3
MA0599.1.4
MA0599.1.5
MA0599.1.6
MA0599.1.7
MA0599.1.8
MA0599.1.9
Publications: Ghaleb A.M, Nandan M.O, Chanchevalap S, Dalton W.B, Hisamuddin I.M, Yang V.W. Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell research 15:92-6 (2005). [Pubmed]
Related annotations: PaperBLAST

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