Transcription Factor
| Accessions: | T049161_1.02 (CISBP 1.02), ZIC1_MOUSE (HOCOMOCO 10), P46684 (JASPAR 2024) |
| Names: | T049161_1.02;, Zic1, ZIC1_MOUSE, Zinc finger protein of the cerebellum 1, Zinc finger protein ZIC 1 |
| Organisms: | Rattus norvegicus, Mus musculus |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:C2H2 ZF |
| Length: | 447 |
| Pfam Domains: | 242-260 C2H2-type zinc finger 275-296 C2H2-type zinc finger 289-314 Zinc-finger double domain 302-326 C2H2-type zinc finger 302-326 Zinc finger, C2H2 type 318-345 Zinc-finger double domain 332-356 C2H2-type zinc finger 350-373 Zinc-finger double domain 362-384 Zinc finger, C2H2 type 362-384 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MLLDAGPQYPAIGVTTFGASRHHSAGDVAERDVGLGINPFADGMGAFKLNPSSHELASAG 60 61 QTAFTSQAPGYAAAAALGHHHHPGHVGSYSSAAFNSTRDFLFRNRGFGDAAAAASAQHSL 120 121 FAASAGGFGGPHGHTDAAGHLLFSGLHEQAAGHASPNVVNGQMRLGFSGDMYPRPEQYGQ 180 181 VTSPRSEHYAAPQLHGYGPMNVNMAAHHGAGAFFRYMRQPIKQELICKWIEPEQLANPKK 240 241 SCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEK 300 301 PFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDK 360 361 PYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPTTDNPTTS 420 421 SMSPSSSAVHHTAGHSALSSNFNEWYV |
| Interface Residues: | 247, 248, 250, 251, 254, 284, 285, 286, 287, 288, 290, 291, 295, 302, 314, 315, 316, 317, 318, 320, 321, 322, 323, 324, 326, 327, 330, 339, 344, 345, 346, 347, 348, 349, 350, 351, 352, 355, 372, 373, 374, 375, 376, 377, 378, 379, 380, 403, 404 |
| 3D-footprint Homologues: | 5v3j_F, 1ubd_C, 7w1m_H, 8cuc_F, 1tf3_A, 7n5w_A, 1tf6_A, 8ssq_A, 6ml4_A, 4x9j_A, 5kkq_D, 8ssu_A, 5ei9_F, 8gn3_A, 2gli_A, 7eyi_G, 5k5i_A, 2i13_A, 7ysf_A, 6wmi_A, 6e94_A, 5und_A, 2lt7_A, 2kmk_A, 6jnm_A, 7y3l_A, 3uk3_C, 1g2f_F, 6u9q_A, 1llm_D, 2v6e_B, 1mey_C, 6blw_A, 5yel_A, 5kl3_A, 8h9h_G, 7y3m_I, 6a57_A, 2jpa_A, 6sjf_B, 5yj3_D, 7txc_E, 5k5l_F, 2wbs_A, 2drp_D, 1f2i_J, 4m9v_C |
| Binding Motifs: | PB0101.1 smCCCCcgGGGGGg PB0205.1 ymdCrCAGCAkGmrw M0412_1.02 crCmrcrkGr ZIC1_MOUSE.H10MO.B|M01421 kGGGwGGks |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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