Transcription Factor

						

			
Accessions: B7ZLG1 (JASPAR 2024)

			
Names: B7ZLG1_HUMAN, Forkhead box protein P3, FOXP3 protein
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: B7ZLG1
Length: 454
Pfam Domains:   360-438 Fork head domain
Sequence: 
(in bold interface residues)		   1 MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS   60
  61 LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV  120
 121 HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD  180
 181 RSVDRAGKDPRPPIPSPDTLCPPSTLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKH  240
 241 CQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDK  300
 301 GSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMR  360
 361 PPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVR  420
 421 VESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP
Interface Residues: 233, 234, 235, 236, 239, 400, 403, 405, 406, 407, 409, 410, 411, 413, 414, 423, 425, 442
3D-footprint Homologues: 5kl3_A, 2jpa_A, 3l2c_A, 7vox_H, 2hdc_A, 7tdx_A, 2c6y_A, 7yzb_A, 6nce_A, 3co6_C, 7vou_C, 7yze_A, 7cby_C, 3g73_A, 6ako_C, 7yzg_A, 7tdw_A, 2a07_J, 7yz7_A, 6el8_A, 2uzk_A, 3qrf_G
Binding Motifs: MA0850.1 rTAAACA
			
Publications: Sadlon TJ, Wilkinson BG, Pederson S, Brown CY, Bresatz S, Gargett T, Melville EL, Peng K, D'Andrea RJ, Glonek GG, Goodall GJ, Zola H, Shannon MF, Barry SC. Genome-wide identification of human FOXP3 target genes in natural regulatory T cells. J Immunol 185:1071-81 (2010). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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