Transcription Factor
| Accessions: | CDX1_DBD (HumanTF 1.0), CDX1 (HT-SELEX2 May2017) |
| Names: | Caudal-type homeobox protein 1, CDX1, CDX1_HUMAN, Homeobox protein CDX-1, ENSG00000113722 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P47902 |
| Notes: | Ensembl ID: ENSG00000113722; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 250 |
| Pfam Domains: | 12-145 Caudal like protein activation region 155-210 Homeobox domain |
| Sequence: (in bold interface residues) | 1 YVGYVLDKDSPVYPGPARPASLGLGPANYGPPAPPPAPPQYPDFSSYSHVEPAPAPPTAW 60 61 GAPFPAPKDDWAAAYGPGPAAPAASPASLAFGPPPDFSPVPAPPGPGPGLLAQPLGGPGT 120 121 PSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITI 180 181 RRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPPQPPMAHDITATPAGPSLG 240 241 GLCPSNTSLL |
| Interface Residues: | 154, 155, 156, 157, 195, 196, 198, 199, 202, 203, 206, 207, 210 |
| 3D-footprint Homologues: | 1puf_A, 1zq3_P, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 6m3d_C, 5flv_I, 1ig7_A, 5zjt_E, 3a01_E, 2h1k_B, 7psx_B, 6a8r_A, 3cmy_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 1fjl_B, 5zfz_A, 4cyc_A, 1le8_A, 1e3o_C, 1au7_A, 7xrc_C, 2xsd_C, 1b72_A, 3l1p_A, 1o4x_A, 8g87_X, 4qtr_D, 1le8_B, 1du0_A, 5hod_A, 4xrm_B, 1mnm_C, 1puf_B, 1k61_B, 3d1n_M |
| Binding Motifs: | CDX1_DBD gymATAAAa CDX1_2 gGYmATAAAac CDX1_methyl_1 kGTCGTAAAwy |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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