Transcription Factor

Accessions: P06798 (JASPAR 2024)
Names: Homeobox protein Hox-1.4, Homeobox protein Hox-A4, Homeobox protein MH-3, HXA4_MOUSE
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P06798
Length: 285
Pfam Domains: 181-237 Homeobox domain
Sequence:
(in bold interface residues)
1 MTMSSFLINSNYIEPKFPPFEEFAPHGGPGGGDGAVGGGPGYPRPQSAPHLPAPNPHAAR 60
61 QPPAYYAPRAREPSYPGGLYPAPAAACPYACRGASPGRPEQSPAPGAHPSPAPQPPVPLG 120
121 HCAPGPTTPAVATGGSAPACPLLLADQGPAGPKGKEPVVYPWMKKIHVSAVNSSYNGGEP 180
181 KRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHK 240
241 LPNTKMRSSNTASAPAGPPGKAQTHSPHHHPHPLPGASTPIPSSI
Interface Residues: 161, 164, 165, 168, 181, 182, 183, 184, 222, 223, 225, 226, 229, 230, 233, 234, 237
3D-footprint Homologues: 5zfz_A, 1fjl_B, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 3d1n_M, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 7q3o_C, 6es3_K, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 4cyc_A, 6m3d_C, 5flv_I, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1o4x_A, 8g87_X, 4qtr_D, 1mnm_C, 1du0_A, 1k61_B, 3l1p_A
Binding Motifs: PH0051.1 grttrtTAATTAackbg
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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