Transcription Factor
| Accessions: | vnd (DrosophilaTF 1.1), P22808 (JASPAR 2024) |
| Names: | Homeobox protein NK-2, Homeobox protein vnd, Protein ventral nervous system defective, VND_DROME |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, JASPAR 2024 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P22808 |
| Length: | 723 |
| Pfam Domains: | 546-602 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MTTSASLERTPSKRDRDRERDNSSGLGSAGSLPASPQSAITVSPSSPATPKRPLRTSTPS 60 61 LERKREREDREDREDRKERQERHERDRDHERFAAVFSTASTTVPTNTSSSSGLAPEQLRI 120 121 PTGAAAFSGFPGLHSMSSLMLPSSAAVAAAAAAPFLPWSPILLPPWNHALLPAAFYPAAL 180 181 RNALPGLFDAKVPSSQRSGFHISDILNLEGSELKNAAAAAAAAAHHGSDLSHHSASESTS 240 241 GHRGQGSHTSPSALSPTPAGVSADEHHNGSGTGGGAGEADHHSTTEHHAPPSHPQQQHPH 300 301 HQQHHHPHLLLPQQHHQQAVAPLPLAHHQSGEAQSHAHANAAAAHLLASHNAAAAAAVAA 360 361 GQYLPNLPKNFPGSFGDEMSSYHHMAQTMLQHSGRSAWIKENELYGTQQPASPDSTSPVT 420 421 SEVSYTYIGSNCQTSPALSGDYKSYSRSADSDALSVGDALHTLHGSSGNGSAGGAPTAHA 480 481 LHNNNNNTTNNNNHSLKAEGINGAGSGHDDSLNEDGIEEDIDDVDDADGSGGGDANGSDG 540 541 LPNKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKT 600 601 KRAQNEKGYEGHPGLLHGHATHPHHPSALPSPRRVAVPVLVRNGKPCLGDSSKLGADCVS 660 661 VSSATATAMQNAAAHHLVALNGAAAYQHAAAAAAGLHAHAHAHAHAHGHGHPHAHAQRAA 720 721 WWP |
| Interface Residues: | 545, 546, 547, 548, 549, 587, 588, 590, 591, 594, 595, 598, 599, 602, 612 |
| 3D-footprint Homologues: | 4j19_B, 1fjl_B, 6a8r_A, 3cmy_A, 1puf_A, 1ig7_A, 3d1n_M, 5zfz_A, 2h1k_B, 3lnq_A, 2lkx_A, 1zq3_P, 1jgg_B, 6m3d_C, 1nk2_P, 7q3o_C, 6es3_K, 3l1p_A, 2ld5_A, 7psx_B, 1au7_A, 5hod_A, 2hdd_A, 1b72_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 4cyc_A, 5flv_I, 5zjt_E, 3a01_E, 1le8_A, 7xrc_C, 2xsd_C, 1e3o_C, 1k61_B, 1o4x_A, 4qtr_D, 1mnm_C, 1du0_A, 8g87_X |
| Binding Motifs: | MA0253.1 TyTCAAGTr vnd dwkTyAAGTGsykk |
| Binding Sites: | vnd_1 vnd_10 / vnd_8 / vnd_9 vnd_11 vnd_12 vnd_13 vnd_14 vnd_15 vnd_16 vnd_17 vnd_18 vnd_19 vnd_2 vnd_20 vnd_21 vnd_22 vnd_23 vnd_24 vnd_25 vnd_26 vnd_27 vnd_28 vnd_29 vnd_3 vnd_30 vnd_31 vnd_32 vnd_33 vnd_34 vnd_35 vnd_36 vnd_37 vnd_38 / vnd_4 vnd_39 / vnd_5 vnd_40 vnd_41 vnd_42 / vnd_7 vnd_43 vnd_44 vnd_45 / vnd_46 vnd_47 vnd_48 vnd_49 vnd_50 vnd_51 vnd_52 vnd_53 vnd_54 vnd_55 vnd_56 vnd_57 vnd_58 vnd_59 vnd_6 vnd_60 vnd_61 vnd_62 vnd_63 vnd_64 vnd_65 vnd_66 vnd_67 vnd_68 vnd_69 vnd_70 vnd_71 vnd_72 vnd_73 vnd_74 vnd_75 vnd_76 vnd_77 vnd_78 vnd_79 vnd_80 vnd_81 vnd_82 vnd_83 vnd_84 vnd_85 vnd_86 vnd_87 MA0253.1.1 / MA0253.1.8 MA0253.1.10 MA0253.1.11 / MA0253.1.17 MA0253.1.12 MA0253.1.13 MA0253.1.14 MA0253.1.15 MA0253.1.16 MA0253.1.18 MA0253.1.19 MA0253.1.2 MA0253.1.20 MA0253.1.3 / MA0253.1.9 MA0253.1.4 MA0253.1.5 MA0253.1.6 MA0253.1.7 |
| Publications: | Wang L.H, Chmelik R, Nirenberg M. Sequence-specific DNA binding by the vnd/NK-2 homeodomain of Drosophila. Proceedings of the National Academy of Sciences of the United States of America 99:12721-6 (2002). [Pubmed] Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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