Transcription Factor

						

			
Accessions: HSF2_HUMAN (HOCOMOCO 10), Q03933 (JASPAR 2024)

			
Names: Heat shock factor protein 2, Heat shock transcription factor 2, HSF 2, HSF2_HUMAN, HSTF 2
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 536
Pfam Domains:     9-113 HSF-type DNA-binding
  229-512 Vertebrate heat shock transcription factor
Sequence: 
(in bold interface residues)		   1 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMAS   60
  61 FVRQLNMYGFRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENK  120
 121 IRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQ  180
 181 FIVTLVQNNQLVSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKVPHSRTEGLKPRE  240
 241 RISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVEDDNEDEYAPVIQ  300
 301 SGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSSLTSEDPVTMMDSILNDNINLLGKVEL  360
 361 LDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMNPTDYINNTKSENKGLETTK  420
 421 NNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASSVEQASTTASSEVLSSVDKP  480
 481 IEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPLDSDMPLLDS
Interface Residues: 54, 55, 60, 62, 63, 64, 66, 67, 109
3D-footprint Homologues: 5hdn_C, 5d5v_B, 5d5w_B, 3hts_B, 7dci_A
Binding Motifs: MA0770.1 TTCTAGAAyrTTC
HSF2_HUMAN.H10MO.A|M01230 vGAAkrTTCtaGAa
			
Publications: Manuel M., Rallu M., Loones M. T., Zimarino V., Mezger V., Morange M. Determination of the consensus binding sequence for the purified embryonic heat shock factor 2.. Eur. J. Biochem. 269:2527-2537 (2002). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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