Transcription Factor
| Accessions: | RORA_HUMAN (HOCOMOCO 10), P35398 (JASPAR 2024) |
| Names: | Nuclear receptor ROR-alpha, Nuclear receptor RZR-alpha, Nuclear receptor subfamily 1 group F member 1, RAR-related orphan receptor A, Retinoid-related orphan receptor-alpha, RORA_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 523 |
| Pfam Domains: | 72-140 Zinc finger, C4 type (two domains) 303-489 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVT 60 61 KKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRT 120 121 SRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAE 180 181 PLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIK 240 241 PEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITW 300 301 QTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGS 360 361 LEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEI 420 421 ALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRAL 480 481 CGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG |
| Interface Residues: | 81, 82, 84, 85, 91, 92, 94, 95, 98, 99, 123, 145, 147, 150, 153 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A |
| Binding Motifs: | RORA_HUMAN.H10MO.B|M01487 wwAwsTAGGTCA MA0071.1 wwcwAGGTCA MA0072.1 wwwAwbTAGGTCAr MA0072.2 wAwbTAGGTCA |
| Binding Sites: | MA0071.1.1 MA0071.1.10 MA0071.1.11 MA0071.1.12 MA0071.1.13 MA0071.1.14 MA0071.1.15 MA0071.1.16 MA0071.1.17 MA0071.1.18 MA0071.1.19 MA0071.1.2 MA0071.1.20 MA0071.1.3 MA0071.1.4 MA0071.1.5 MA0071.1.6 MA0071.1.7 MA0071.1.8 MA0071.1.9 MA0072.1.1 MA0072.1.10 MA0072.1.11 MA0072.1.12 MA0072.1.13 MA0072.1.14 MA0072.1.15 MA0072.1.16 MA0072.1.17 MA0072.1.18 MA0072.1.19 MA0072.1.2 MA0072.1.20 MA0072.1.3 MA0072.1.4 MA0072.1.5 MA0072.1.6 MA0072.1.7 MA0072.1.8 MA0072.1.9 MA0072.2.1 MA0072.2.10 MA0072.2.11 MA0072.2.12 MA0072.2.13 MA0072.2.14 MA0072.2.15 MA0072.2.16 MA0072.2.17 MA0072.2.18 MA0072.2.19 MA0072.2.2 MA0072.2.20 MA0072.2.3 MA0072.2.4 MA0072.2.5 MA0072.2.6 MA0072.2.7 MA0072.2.8 MA0072.2.9 |
| Publications: | Giguere V., Tini M., Flock G., Ong E., Evans R. M., Otulakowski G. Isoform-specific amino-terminal domains dictate DNA-binding properties of RORalpha, a novel family of orphan hormone nuclear receptors. Genes Dev. 8:538-553 (1994). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.