Transcription Factor

Accessions: HNF6_HUMAN (HOCOMOCO 10), Q9UBC0 (JASPAR 2024)
Names: Hepatocyte nuclear factor 6, HNF-6, HNF6_HUMAN, One cut domain family member 1, One cut homeobox 1
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 465
Pfam Domains: 286-365 CUT domain
386-439 Homeobox domain
Sequence:
(in bold interface residues)
1 MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVAHRGSHLPPAHPRSMGMASLLD 60
61 GGSGGGDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTTYTTLTPLQPLPPISTVSD 120
121 KFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLS 180
181 PLSSSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHLTPTSAG 240
241 MVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQR 300
301 ITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQ 360
361 RMSALRLAACKRKEQEHGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQ 420
421 QLGLELSTVSNFFMNARRRSLDKWQDEGSSNSGNSSSSSSTCTKA
Interface Residues: 316, 317, 318, 321, 322, 323, 324, 326, 328, 329, 332, 336, 362, 380, 387, 388, 389, 430, 431, 434, 435, 438, 439, 440, 441, 444
3D-footprint Homologues: 1au7_A, 2o4a_A, 2d5v_B, 6fqp_B, 6m3d_C, 6es3_K, 7q3o_C, 3l1p_A, 1jgg_B, 4xrs_G, 2hdd_A, 3rkq_B, 5hod_A, 2hos_A, 1e3o_C, 8g87_X, 6fqq_E, 1o4x_A, 1du0_A, 4qtr_D, 1puf_B, 4xrm_B
Binding Motifs: MA0679.1 aaaAAATCrATAhy
HNF6_HUMAN.H10MO.C|M01227 wwTATTGAYTtwdw
MA0679.2 aaaaAATCAATAawww
MA0679.3 aAATCAATA
Binding Sites: MA0679.2.1
MA0679.2.10 / MA0679.2.8
MA0679.2.10 / MA0679.2.11
MA0679.2.11 / MA0679.2.12
MA0679.2.13
MA0679.2.14
MA0679.2.14 / MA0679.2.15
MA0679.2.15 / MA0679.2.16
MA0679.2.17
MA0679.2.16 / MA0679.2.18
MA0679.2.17 / MA0679.2.19
MA0679.2.2
MA0679.2.20
MA0679.2.3
MA0679.2.4
MA0679.2.5
MA0679.2.5 / MA0679.2.6
MA0679.2.6 / MA0679.2.7
MA0679.2.7 / MA0679.2.8
MA0679.2.9
MA0679.2.12
MA0679.2.18
MA0679.2.19
MA0679.2.20
MA0679.2.9
MA0679.3.1
MA0679.3.10 / MA0679.3.14 / MA0679.3.2 / MA0679.3.20
MA0679.3.11
MA0679.3.12
MA0679.3.13
MA0679.3.15
MA0679.3.16
MA0679.3.17
MA0679.3.18
MA0679.3.19
MA0679.3.3 / MA0679.3.6
MA0679.3.4 / MA0679.3.5
MA0679.3.7
MA0679.3.8
MA0679.3.9
Publications: Samadani U., Costa R. H. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol. Cell. Biol. 16:6273-6284 (1996). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.