Transcription Factor

Accessions: O70137 (JASPAR 2024)
Names: ALX3_MOUSE, Homeobox protein aristaless-like 3, Proline-rich transcription factor ALX3
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 343
Pfam Domains: 154-210 Homeobox domain
Sequence:
(in bold interface residues)
1 MDPERCAPFSVGPAAGPYAAAGDEAPGPQGTPDAAPHLHPAPPRGPRLSRFPACGPLEPY 60
61 LPEPAKPPAKYLQDLGPGPVLNGGHFYEGSAEAEEKASKAASFPQLPVDCRGGPRDGPSN 120
121 VQASPGPCLASLSVPLSPGLPDSMELAKTKSKKRRNRTTFSTFQLEELEKVFQKTHYPDV 180
181 YAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKMQEGRNPFTTAYDISVLPRTDSHP 240
241 QLQNSLWPSPGSGSPGGPCLMSPEGIPSPCMSPYSHSHGNVAGFMGVPASPAAHPGIYSI 300
301 HGFPPALGGHSFEPSPDGDYKSPSLVSLRMKPKEPPGLLNWTT
Interface Residues: 104, 105, 106, 110, 111, 123, 126, 153, 154, 155, 156, 157, 195, 196, 198, 199, 202, 203, 206, 207, 210, 211, 221
3D-footprint Homologues: 1au7_A, 4j19_B, 1fjl_B, 3cmy_A, 2h1k_B, 1ig7_A, 1puf_A, 6a8r_A, 3d1n_M, 1puf_B, 5zfz_A, 1zq3_P, 6m3d_C, 3lnq_A, 1nk2_P, 2lkx_A, 1jgg_B, 2ld5_A, 6es3_K, 7q3o_C, 5flv_I, 1b72_A, 5zjt_E, 5hod_A, 3rkq_B, 2hdd_A, 7psx_B, 5jlw_D, 4cyc_A, 2r5y_A, 4xrs_G, 3l1p_A, 2hos_A, 3a01_E, 1e3o_C, 1le8_A, 4qtr_D, 6wig_A, 1du0_A, 4xrm_B
Binding Motifs: PH0001.1 wawayTAATTAryTsav
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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