Transcription Factor
| Accessions: | FOXI1_HUMAN (HOCOMOCO 10), Q12951 (JASPAR 2024) |
| Names: | Forkhead box protein I1, Forkhead-related protein FKHL10, Forkhead-related transcription factor 6, FOXI1_HUMAN, FREAC-6, Hepatocyte nuclear factor 3 forkhead homolog 3, HFH-3, HNF-3/fork-head homolog 3 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q12951 |
| Length: | 378 |
| Pfam Domains: | 123-218 Fork head domain |
| Sequence: (in bold interface residues) | 1 MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPN 60 61 PYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMK 120 121 LVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDC 180 181 FKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTESSLPV 240 241 DSPKTTEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGSPTSHPLV 300 301 TPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHF 360 361 YNSVNTSGVLYPREGTEV |
| Interface Residues: | 163, 166, 168, 169, 170, 172, 173, 174, 176, 177, 186, 193, 218 |
| 3D-footprint Homologues: | 3l2c_A, 7vox_H, 2hdc_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 3qrf_G |
| Binding Motifs: | MA0042.2 GTAAACA UN0496.1 AsCGGAArTrTmAACAk UN0497.1 rCCGGAAGsWmArCAk MA1935.1 rtaaACmGGAArtr MA1946.1 GtMAACMGGAwGy FOXI1_HUMAN.H10MO.B|M01155 yTyTGATTGGyy MA0042.1 ksdTrTTTrTwT MA1935.2 aaACmGGAAr MA1946.2 GtMAACMGGAwG UN0496.2 AsCGGAArTrTmAACA |
| Publications: | Overdier D. G., Ye H., Peterson R. S., Clevidence D.E., Costa R. H. The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult kidney. J. Biol. Chem. 272:13725-13730 (1997). [Pubmed] Nakagawa S, Gisselbrecht SS, Rogers JM, Hartl DL, Bulyk ML. DNA-binding specificity changes in the evolution of forkhead transcription factors. Proc Natl Acad Sci U S A 110:12349-54 (2013). [Pubmed] Ibarra IL, Hollmann NM, Klaus B, Augsten S, Velten B, Hennig J, Zaugg JB. Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions. Nat Commun 11:124 (2020). [Pubmed] |
| Related annotations: | PaperBLAST |
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