Transcription Factor
| Accessions: | O35690 (JASPAR 2024), Q99453 (JASPAR 2024) |
| Names: | NBPhox, Neuroblastoma Phox, Paired mesoderm homeobox protein 2B, Paired-like homeobox 2B, PHOX2B homeodomain protein, PHX2B_MOUSE, PHX2B_HUMAN |
| Organisms: | Mus musculus, Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 314 |
| Pfam Domains: | 99-155 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSL 60 61 TPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAET 120 121 HYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSR 180 181 DDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGG 240 241 AAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQR 300 301 PNGAKAALVKSSMF |
| Interface Residues: | 98, 99, 100, 101, 102, 140, 141, 143, 144, 147, 148, 151, 152, 155 |
| 3D-footprint Homologues: | 4j19_B, 1nk2_P, 1ig7_A, 6a8r_A, 3cmy_A, 2h1k_B, 1puf_A, 3d1n_M, 5zfz_A, 1fjl_B, 1zq3_P, 3lnq_A, 1jgg_B, 2lkx_A, 2ld5_A, 6es3_K, 7q3o_C, 1b72_A, 5zjt_E, 3a01_E, 5hod_A, 7psx_B, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 1au7_A, 4cyc_A, 2r5y_A, 1puf_B, 6m3d_C, 5flv_I, 3l1p_A, 2hos_A, 1e3o_C, 1le8_A, 6wig_A, 1o4x_A, 1du0_A, 4qtr_D, 8g87_X |
| Binding Motifs: | MA0681.1 TAAyyyAATTA PH0136.1 vrkaaTTAATTAAyrsg MA0681.2 wwTAATCAAATTAwww MA0681.3 TAATCAAATTAw |
| Binding Sites: | MA0681.3.16 / MA0681.3.17 MA0681.2.1 MA0681.2.10 MA0681.2.11 / MA0681.2.3 MA0681.2.12 MA0681.2.13 MA0681.2.14 MA0681.2.15 / MA0681.2.4 MA0681.2.16 / MA0681.2.5 MA0681.2.17 / MA0681.2.6 MA0681.2.18 MA0681.2.19 MA0681.2.2 MA0681.2.20 / MA0681.2.7 MA0681.2.3 MA0681.2.4 MA0681.2.5 MA0681.2.6 MA0681.2.1 / MA0681.2.7 MA0681.2.8 MA0681.2.2 / MA0681.2.9 MA0681.2.10 MA0681.2.11 MA0681.2.12 MA0681.2.13 MA0681.2.14 MA0681.2.15 MA0681.2.16 / MA0681.2.17 MA0681.2.18 MA0681.2.19 MA0681.2.20 MA0681.2.8 MA0681.2.9 MA0681.3.1 MA0681.3.10 MA0681.3.11 / MA0681.3.3 MA0681.3.12 / MA0681.3.13 MA0681.3.14 MA0681.3.15 MA0681.3.18 MA0681.3.19 MA0681.3.2 MA0681.3.20 MA0681.3.4 MA0681.3.5 MA0681.3.6 MA0681.3.7 MA0681.3.8 MA0681.3.9 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Vincentz JW, VanDusen NJ, Fleming AB, Rubart M, Firulli BA, Howard MJ, Firulli AB. A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis. J Neurosci 32:2110-20 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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