Transcription Factor
| Accessions: | T025274_1.02 (CISBP 1.02), Q9BYV9 (JASPAR 2024) |
| Names: | BACH2, T025274_1.02;, BACH2_HUMAN, BTB and CNC homolog 2, Transcription regulator protein BACH2 |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | family:bZIP |
| Length: | 841 |
| Pfam Domains: | 27-132 BTB/POZ domain 651-698 bZIP transcription factor 651-696 Basic region leucine zipper |
| Sequence: (in bold interface residues) | 1 MSVDEKPDSPMYVYESTVHCTNILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSE 60 61 YFWQALVGQTKNDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHN 120 121 LEDSCFSFLQTQLLNSEDGLFVCRKDAACQRPHEDCENSAGEEEDEEEETMDSETAKMAC 180 181 PRDQMLPEPISFEAAAIPVAEKEEALLPEPDVPTDTKESSEKDALTQYPRYKKYQLACTK 240 241 NVYNASSHSTSGFASTFREDNSSNSLKPGLARGQIKSEPPSEENEEESITLCLSGDEPDA 300 301 KDRAGDVEMDRKQPSPAPTPTAPAGAACLERSRSVASPSCLRSLFSITKSVELSGLPSTS 360 361 QQHFARSPACPFDKGITQGDLKTDYTPFTGNYGQPHVGQKEVSNFTMGSPLRGPGLEALC 420 421 KQEGELDRRSVIFSSSACDQVSTSVHSYSGVSSLDKDLSEPVPKGLWVGAGQSLPSSQAY 480 481 SHGGLMADHLPGRMRPNTSCPVPIKVCPRSPPLETRTRTSSSCSSYSYAEDGSGGSPCSL 540 541 PLCEFSSSPCSQGARFLATEHQEPGLMGDGMYNQVRPQIKCEQSYGTNSSDESGSFSEAD 600 601 SESCPVQDRGQEVKLPFPVDQITDLPRNDFQMMIKMHKLTSEQLEFIHDVRRRSKNRIAA 660 661 QRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNQLKACMGELLDNFSCLSQEVCRDIQSP 720 721 EQIQALHRYCPVLRPMDLPTASSINPAPLGAEQNIAASQCAVGENVPCCLEPGAAPPGPP 780 781 WAPSNTSENCTSGRRLEGTDPGTFSERGPPLEPRSQTVTVDFCQEMTDKCTTDEQPRKDY 840 841 T |
| Interface Residues: | 652, 656, 657, 659, 660, 663, 664, 667 |
| 3D-footprint Homologues: | 1skn_P, 2wt7_B, 7x5e_F, 4eot_A, 5t01_B, 5vpe_D |
| Binding Motifs: | M2980_1.02 srTGACTCAys MA1101.2 awasCATGAsTCATsvtwt MA1470.1 awAbsATGACGTSATsmTWt MA1101.1 smTGACTCAGCAdw MA1101.3 CATGAsTCATs MA1470.2 awAbsATGACGTSATsmTW |
| Binding Sites: | MA1101.1.1 MA1101.1.10 MA1101.1.11 MA1101.1.12 MA1101.1.13 MA1101.1.14 MA1101.1.15 MA1101.1.16 MA1101.1.17 MA1101.1.18 MA1101.1.19 MA1101.1.2 MA1101.1.20 MA1101.1.3 MA1101.1.4 MA1101.1.5 MA1101.1.6 MA1101.1.7 MA1101.1.8 MA1101.1.9 |
| Publications: | Oyake T., Itoh K., Motohashi H., Hayashi N., Hoshino H., Nishizawa M., Yamamoto M., Igarashi K. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol. Cell. Biol. 16:6083-6095 (1996). [Pubmed] Igarashi K, Kurosaki T, Roychoudhuri R. BACH transcription factors in innate and adaptive immunity. Nat Rev Immunol 17:437-450 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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