Transcription Factor

						

			
Accessions: Q00653 (JASPAR 2024)

			
Names: DNA-binding factor KBF2, H2TF1, Lymphocyte translocation chromosome 10 protein, Lyt10, NFKB2_HUMAN, Nuclear factor NF-kappa-B p100 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, Oncogene Lyt-10
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 900
Pfam Domains:    40-220 Rel homology domain (RHD)
  487-509 Ankyrin repeat
  522-567 Ankyrin repeats (many copies)
  522-586 Ankyrin repeats (3 copies)
  528-553 Ankyrin repeat
  528-557 Ankyrin repeat
  529-582 Ankyrin repeats (many copies)
  573-655 Ankyrin repeats (3 copies)
  600-629 Ankyrin repeat
  605-698 Ankyrin repeats (3 copies)
  634-665 Ankyrin repeat
  668-696 Ankyrin repeat
  668-698 Ankyrin repeat
  779-848 Death domain
Sequence: 
(in bold interface residues)		   1 MESCYNPGLDGIIEYDDFKLNSSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGP   60
  61 SHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGIC  120
 121 AVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKE  180
 181 LKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSV  240
 241 RGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIE  300
 301 RPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGGS  360
 361 GGAAGGYGGAGGGGSLGFFPSSLAYSPYQSGAGPMGCYPGGGGGAQMAATVPSRDSGEEA  420
 421 AEPSAPSRTPQCEPQAPEMLQRAREYNARLFGLAQRSARALLDYGVTADARALLAGQRHL  480
 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT  540
 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG  600
 601 LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN  660
 661 VNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGP  720
 721 EKDTRSSFRGHTPLDLTCSTKVKTLLLNAAQNTMEPPLTPPSPAGPGLSLGDTALQNLEQ  780
 781 LLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSDMGL  840
 841 EEGVRLLRGPETRDKLPSTAEVKEDSAYGSQSVEQEAEKLGPPPEPPGGLCHGHPQPQVH  900
Interface Residues: 52, 54, 55, 57, 58, 60, 61, 62, 221, 223, 252, 283, 597, 628, 629
3D-footprint Homologues: 1gji_A, 2ram_A, 1imh_C, 7cli_B, 1nfk_A, 1a3q_A, 2o61_A, 8j0k_B
Binding Motifs: MA0778.1 aGGGGAwTCCCCy
MA0778.2 GGGGAwTCCCC
			
Publications: Wan F, Lenardo MJ. Specification of DNA binding activity of NF-kappaB proteins. Cold Spring Harb Perspect Biol : (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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