Transcription Factor
| Accessions: | T161884_1.02 (CISBP 1.02), P12383 (JASPAR 2024) |
| Names: | PDR1, T161884_1.02;, PDR1_YEAST, Pleiotropic drug resistance protein 1, Transcription factor PDR1 |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Zinc cluster |
| Length: | 1068 |
| Pfam Domains: | 44-77 Fungal Zn(2)-Cys(6) binuclear cluster domain 308-653 Fungal specific transcription factor domain |
| Sequence: (in bold interface residues) | 1 MRGLTPKNGVHIETGPDTESSADSSNFSTGFSGKIRKPRSKVSKACDNCRKRKIKCNGKF 60 61 PCASCEIYSCECTFSTRQGGARIKNLHKTSLEGTTVQVKEETDSSSTSFSNPQRCTDGPC 120 121 AVEQPTKFFENFKLGGRSSGDNSGSDGKNDDDVNRNGFYEDDSESQATLTSLQTTLKNLK 180 181 EMAHLGTHVTSAIESIELQISDLLKRWEPKVRTKELATTKFYPNKSIETQLMKNKYCDVV 240 241 HLTRYAAWSNNKKDQDTSSQPLIDEIFGLYSPFQFLSLQGIGKCFQNYRSKSKCEIFPRT 300 301 AKETIYIMLRFFDVCFHHINQGCVSIANPLENYLQKMNLLPSTPSSISSAGSPNTAHTKS 360 361 HVALVINHLPQPFVRNITGISNSELLSEMNNDISMFGILLKMLDMHKNSYQNFLMEITSN 420 421 PSVAKNTQSIDVLQEFIHYCQAGEALIALCYSYYNSTLYNYVDFTCDITHLEQLLYFLDL 480 481 LFWLSEIYGFEKVLNVAVHFVSRVGLSRWEFYVGLDENFAERRRNLWWKAFYFEKTLASK 540 541 LGYPSNIDDSKINCLLPKNFRDVGFLDNRDFIENVHLVRRSEAFDNMCISDLKYYGELAV 600 601 LQIVSHFSSSVLFNEKFTSIRNTSKPSVVREKLLFEVLEIFNETEMKYDAIKEQTGKLFD 660 661 IAFSKDSTELKVSREDKIMASKFVLFYEHHFCRMVNESDNIVARLCVHRRPSILIENLKI 720 721 YLHKIYKSWTDMNKILLDFDNDYSVYRSFAHYSISCIILVSQAFSVAEFIKVNDVVNMIR 780 781 VFKRFLDIKIFSENETNEHVFNSQSFKDYTRAFSFLTIVTRIMLLAYGESSSTNLDVISK 840 841 YIDENAPDLKGIIELVLDTNSCAYRFLLEPVQKSGFHLTVSQMLKNRKFQEPLMSNEDNK 900 901 QMKHNSGKNLNPDLPSLKTGTSCLLNGIESPQLPFNGRSAPSPVRNNSLPEFAQLPSFRS 960 961 LSVSDMINPDYAQPTNGQNNTQVQSNKPINAQQQIPTSVQVPFMNTNEINNNNNNNNNNK 1020 1021 NNINNINNNNSNNFSATSFNLGTLDEFVNNGDLEDLYSILWSDVYPDS |
| Interface Residues: | 39, 40, 41, 50, 52, 53, 54, 55, 67, 68 |
| 3D-footprint Homologues: | 1f5e_P, 6o19_A, 1hwt_C, 1pyi_A, 3coq_A, 6gys_C, 1d66_B, 1zme_D, 7uik_T |
| Binding Motifs: | M1787_1.02 gTTCCGkg MA0352.1 yCCGCGGa MA0352.2 skTTCCrCGGAAvr MA0352.3 TTCCrCGGAA |
| Binding Sites: | MA0352.3.2 / MA0352.3.3 MA0352.3.10 MA0352.2.1 MA0352.2.10 / MA0352.2.11 MA0352.2.11 / MA0352.2.12 MA0352.2.12 / MA0352.2.13 MA0352.2.13 / MA0352.2.16 / MA0352.2.17 MA0352.2.14 / MA0352.2.17 / MA0352.2.18 MA0352.2.15 / MA0352.2.16 / MA0352.2.19 MA0352.2.2 MA0352.2.20 MA0352.2.3 MA0352.2.4 MA0352.2.5 MA0352.2.6 MA0352.2.7 / MA0352.2.8 MA0352.2.8 / MA0352.2.9 MA0352.2.10 / MA0352.2.9 MA0352.2.14 MA0352.2.15 MA0352.2.18 / MA0352.2.20 MA0352.2.7 MA0352.3.1 MA0352.3.11 MA0352.3.12 MA0352.3.13 / MA0352.3.17 MA0352.3.14 / MA0352.3.18 MA0352.3.15 / MA0352.3.16 / MA0352.3.19 / MA0352.3.9 MA0352.3.20 MA0352.3.4 MA0352.3.5 MA0352.3.6 MA0352.3.7 MA0352.3.8 |
| Publications: | Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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